Aquaporin-4 expression is increased in oedematous human brain tumours
Aquaporin-4 expression is increased in oedematous human brain tumours
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DOI：
10.1136/jnnp.72.2.262
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发表时间：
2002-02-01
影响因子：
11
通讯作者：
Bell, BA
中科院分区：
文献类型：
--
作者：
Saadoun, S;Papadopoulos, MC;Bell, BA
水通道蛋白4（AQP 4）是一种高度保守的水通道蛋白。在大鼠中，AQP 4在星形胶质细胞足突中表达，并且在脑水稳态中是重要的。在非肿瘤性人脑或水肿性脑肿瘤中，水稳态被破坏，AQP 4的表达尚未被研究。因此，免疫组化被用来研究AQP 4在非肿瘤性和肿瘤性人脑中的表达，并使用对比增强的计算机断层扫描评估血脑屏障通透性。AQP 4存在于五个非肿瘤性脑标本和五个低级别（Daumas-Duport I或II）星形细胞瘤的微血管周围。AQP 4在4例中大量上调，在1例高级别（Daumas-Duport III或IV）星形细胞瘤中缺失。在5例转移性腺癌的反应性星形胶质细胞中也发现了AQP 4的大量上调。有显著性差异（p
Aquaporin-4 (AQP4) is a highly conserved water channel protein. In rats, AQP4 is expressed in astrocyte foot processes and is important in brain water homeostasis. AQP4 expression has not been investigated in non-neoplastic human brain or oedematous brain tumours, where water homeostasis is disrupted. Therefore, immunohistochemistry was used to study AQP4 expression in non-neoplastic and neoplastic human brain and blood-brain barrier permeability was assessed using contrast enhanced computed tomograms. AQP4 was present around microvessels in five specimens of non-neoplastic brain and five low grade (Daumas-Duport I or II) astrocytomas. AQP4 was massively upregulated in four and absent in one high grade (Daumas-Duport III or IV) astrocytoma. Massive upregulation of AQP4 was also found in reactive astrocytes in five metastatic adenocarcinomas. There was significant (p