Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein
Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein
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DOI：
10.1128/iai.70.9.4897-4901.2002
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发表时间：
2002-09-01
影响因子：
3.1
通讯作者：
Brodeur, BR
中科院分区：
文献类型：
--
作者：
Martin, D;Rioux, S;Brodeur, BR
采用小鼠新生儿感染模型，测定抗B组链球菌（GBS） Sip表面蛋白抗体的保护作用。兔sip特异性抗体被动给予怀孕小鼠保护幼鼠免受GBS致命挑战。此外，用纯化的重组Sip蛋白主动免疫雌性CD-1小鼠可诱导产生特异性抗体，这些抗体也可保护新生幼崽免受Ia/c、Ib、II、III和v血清型GBS菌株的感染。这些数据证实，Sip特异性抗体可以穿过胎盘，并对GBS感染产生保护性免疫。
The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.