Fetal growth: Boys before girls
Fetal growth: Boys before girls
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DOI：
10.1159/000023382
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发表时间：
1999-05-01
期刊：
影响因子：
--
通讯作者：
Eeckels, R
中科院分区：
文献类型：
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作者：
de Zegher, F;Devlieger, H;Eeckels, R
在足月分娩时，男孩比女孩重。这种差异被认为部分是由雄激素作用产生的;其时间过程尚未被破译。雄激素的作用不仅可能增加体重增加，但也可能改变其时间进程。我们通过检查281,894名体重在500- 4749 g之间的男孩和女孩的胎龄差异来验证这一假设。发现具有给定体重的儿童出生的年龄取决于性别：男孩始终比女孩年轻（p < 0.001），年龄差异在出生体重较低的班级中最为明显。因此，胎儿生长的性别差异在孕晚期之前似乎相当明显，而在足月时相对不那么明显。总之，男性孕体似乎不仅比女性发育得更快，而且发育得更早。因此，一些关键的时间窗口的发展可能略有不同，男孩和女孩，这种现象可能是性别差异的敏感性胎儿编程的基础之一。版权所有（C）1999 S. Karger AG，巴塞尔。
At term birth, boys are heavier than girls. This difference is thought to be generated in part by androgen action; its time course has not been deciphered. Androgen action may not only increase weight gain,but may also alter its time course. We have tested this hypothesis by examining the difference in gestational age of 281,894 boys and girls with weights between 500-4,749 g, The age at which children are born with a given weight was found to depend on gender: boys were consistently younger than girls (p < 0.001), the age difference being most pronounced in the lower birth weight classes. Thus, the gender difference in fetal growth appears to be rather pronounced before the third trimester and relatively less marked towards term. In conclusion, the male conceptus seems to grow not only more, but also earlier than the female. Hence, some critical time windows of development may be slightly different in boys and girls, and this phenomenon may be one of the bases for gender differences in the sensitivity to fetal programming. Copyright (C) 1999 S. Karger AG, Basel.