Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure.
Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure.
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慢性甲状腺素、3,5,3 和 3,3,5-三碘甲状腺原氨酸、3,5-、3,3- 和 3,5- 二碘甲状腺原氨酸以及 3-单碘甲状腺原氨酸的同时周转研究
DOI：
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发表时间：
1983
影响因子：
5.8
通讯作者：
T. Friis
中科院分区：
文献类型：
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作者：
J. Faber;J. Heaf;C. Kirkegaard;I. B. Lumholtz;K. Siersbaek;K. Kølendorf;T. Friis
本研究评估了慢性肾功能衰竭(CRF)患者甲状腺激素通过三碘、二碘和一碘甲腺原氨酸进行的甲状腺外单次序贯脱碘治疗。对6例CRF患者进行了T4、T3、rT3、3，5-二碘甲腺原氨酸(3，5-T2)、3，3‘-T2、3’，5‘-T2、3’-5‘-T2和3’-单碘甲腺原氨酸(3-T1)的同时代谢研究。血清T4、T3和3，5-T2水平下降到对照组的三分之二(P<0.05)，而RT3和3，3‘-T2水平下降到较小程度。血清3‘-5’-T1增加一倍(p<0.05)。T4、RT3和3‘，5’-T2的MCR分别增加到正常的168%、127%和187%(P<0.05)，而T3、3，5-T2、3，3‘-T2和3’-T1的MCR无明显变化。CRF中碘甲状腺原氨酸的平均产生率(PR)如下(CRF与对照组相比，以纳米分子/天/70公斤为单位)：T4,119对125；T3，26对44(P<0.001)；RT3，49对48；3，5-T2，3.5vs.7.2(P<0.001)；3，3‘-T2，25对35(P<0.01)；3’，5‘-T2，25对14(P<0.01)；以及3’-T1，39对30(P<0.01)。以前的研究已经证明，CRF中T4的酚环(5‘-)脱碘减少，这与目前发现的T4的PR没有改变和T3的PR减少是一致的。相反，由于T3到3，5-T2(PR 3，5-T2/PR T3)的转化率(CR)没有改变(16%比对照组的15%)，CRF对T3的5‘-脱碘反应导致3，5-T2的形成没有影响。CRF患者T4到RT3的酪氨酸环(5-)脱碘不受影响，CR为42%，对照组为40%，而RT3到3‘，5’-T2的CR增强(53%比29%，P<0.01)，这也是一个5-脱碘步骤。总之，我们的数据表明，CRF深刻地改变了所有所研究的碘甲状腺原氨酸的动力学。此外，我们的数据与人类中存在多于一个的5‘-脱碘酶以及多于一个的5-脱碘酶是一致的。
The present study evaluates the sequential extra-thyroidal monodeiodination of thyroid hormones through tri-, di-, and monoiodothyronines in chronic renal failure (CRF) in man. Simultaneous turnover studies of T4, T3, rT3, 3,5-diiodothyronine (3,5-T2), 3,3'-T2, 3',5'-T2, 3'5'-T2, and 3'-monoiodothyronine (3--T1) were conducted in six patients with CRF (creatinine clearance, 9-18 ml/min) using the single-injection, noncompartmental approach. Serum levels of T4, T3, and 3,5-T2 were reduced to two thirds of control levels (P less than 0.05), whereas serum rT3 and 3,3'-T2 levels were reduced to a minor degree. Serum 3'-5'-T1 was doubled (p less than 0.05). The MCRs of T4, rT3, and 3',5'-T2 were enhanced to 168%, 127%, and 187% of normal (P less than 0.05), respectively, whereas those of T3, 3,5-T2, 3,3'-T2, and 3'-T1 were unaffected. The mean production rates (PRs) of the iodothyronines in CRF were as follows (CRF vs. control values, expressed as nanomoles per day/70 kg): T4, 119 vs. 125; T3, 26 vs. 44 (P less than 0.01); rT3, 49 vs, 48; 3,5-T2, 3.5 vs. 7.2 (P less than 0.001); 3,3'-T2, 25 vs. 35 (P less than 0.01); 3',5'-T2, 25 vs. 14 (P less than 0.01); and 3'-T1, 39 vs. 30. Previous studies have demonstrated reduced phenolic ring (5'-) deiodination of T4 in CRF, which is supported by the present finding of unaltered PR of T4 and reduced PR of T3. In contrast the 5'-deiodination of T3 leading to the formation of 3,5-T2 was found unaffected by CRF, since the conversion rate (CR) of T3 to 3,5-T2 (PR 3,5-T2/PR T3) was unaltered (16% vs. 15% in controls). The tyrosylic ring (5-) deiodination of T4 to rT3 was unaffected in patients with CRF, the CR being 42% vs. 40% in controls, in contrast to an enhanced CR of rT3 to 3',5'-T2 (53% vs. 29%, P less than 0.01), which also is a 5-deiodination step. In conclusion, our data show that CRF profoundly changes the kinetics of all iodothyronines studied. Furthermore, our data are compatible with the existence of more than one 5'-deiodinase as well as more than one 5-deiodinase in man.