FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy
FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy
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DOI：
10.3233/jad-171152
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Small, Gary W.
中科院分区：
文献类型：
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作者：
Chen, Stephen T.;Siddarth, Prabha;Small, Gary W.
背景资料：我们的研究小组已经表明，在体内tau蛋白脑结合模式从FDDNP-PET扫描在退休的职业足球运动员怀疑慢性创伤性脑病不同的tau蛋白和淀粉样蛋白聚集体结合观察阿尔茨海默病（AD）患者和认知功能完好的controls.Objective：比较这些发现与军事人员的轻度创伤性脑损伤（mTBI）的历史。方法：FDDNP-PET脑扫描在7名军事人员和15名有mTBI病史和认知和/或情绪症状的退役球员，24名AD患者和28名认知完整的对照组中进行了比较。非参数ANCOVA与Tukey-Kramer调整的事后比较被用来测试的显着差异，在区域FDDNP绑定subjectsgroups.Results：FDDNP脑结合是较高的军事人员相比，对照组在杏仁核，中脑，丘脑，脑桥，额叶和前，后扣带区（p < 0.01-0.0001）。军事人员的结合模式与运动员的结合模式相似，但杏仁核和纹状体除外（运动员的结合更高; p = 0.02-0.003）。与AD组相比，军人组在中脑表现出更高的结合（p = 0.0008）和脑桥（p = 0.002），内侧颞叶、外侧颞叶和顶叶区域的结合较低（所有p = 0.02）。这项对有mTBI病史的军事人员体内tau蛋白和淀粉样蛋白脑信号的首次研究显示，结合模式与退休人员相似。足球运动员和不同的结合模式，在AD和正常老化，这表明FDDNP-PET的早期检测和治疗监测在不同的风险人群的潜在价值。
Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls.Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury (mTBI).Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups.Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p < 0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p = 0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p = 0.0008) and pons (p = 0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p = 0.02).Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.