Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics.
Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics.
复制标题
DOI：
10.1111/bph.15682
复制
发表时间：
2022-03
影响因子：
7.3
通讯作者：
Williams KW
中科院分区：
文献类型：
--
作者：
Kabahizi A;Wallace B;Lieu L;Chau D;Dong Y;Hwang ES;Williams KW
胰高血糖素样肽-1（GLP-1）来源于肠内分泌细胞和尾髓质中的离散神经元群，通过体液和神经通路发挥作用，调节饱腹感、胃运动和胰腺内分泌功能。这些生理属性有助于GLP-1在血液调节和慢性体重管理中具有有效的治疗作用。在这篇综述中，我们提供了内源性与外源性GLP-1和相关药物靶向神经回路的概述。我们还强调了负责GLP-1和GLP-1受体激动剂对能量平衡和葡萄糖代谢的急性和慢性影响的神经元和细胞机制的候选亚群。最后，我们提出了潜在的未来方向，将这些发现转化为治疗代谢性疾病的有效疗法的发展。这篇文章是GLP 1受体配体（BJP 75周年纪念）主题问题的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
Glucagon‐like‐peptide‐1 (GLP‐1) derived from gut enteroendocrine cells and a discrete population of neurons in the caudal medulla acts through humoral and neural pathways to regulate satiety, gastric motility and pancreatic endocrine function. These physiological attributes contribute to GLP‐1 having a potent therapeutic action in glycaemic regulation and chronic weight management. In this review, we provide an overview of the neural circuits targeted by endogenous versus exogenous GLP‐1 and related drugs. We also highlight candidate subpopulations of neurons and cellular mechanisms responsible for the acute and chronic effects of GLP‐1 and GLP‐1 receptor agonists on energy balance and glucose metabolism. Finally, we present potential future directions to translate these findings towards the development of effective therapies for treatment of metabolic disease. This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
登录
查看更多内容
下丘脑胰高血糖素样肽1受体足够，但对于调节小鼠的能量平衡和葡萄糖稳态不需要。
影响因子：
7.7
作者：
Burmeister MA;Ayala JE;Smouse H;Landivar-Rocha A;Brown JD;Drucker DJ;Stoffers DA;Sandoval DA;Seeley RJ;Ayala JE
通讯作者：
Ayala JE
影响因子：
2.7
作者：
Abtahi S;Howell E;Salvucci JT;Bastacky JMR;Dunn DP;Currie PJ
通讯作者：
Currie PJ
影响因子：
7.7
作者：
Adams JM;Pei H;Sandoval DA;Seeley RJ;Chang RB;Liberles SD;Olson DP
通讯作者：
Olson DP
影响因子：
56.9
作者：
Bouret, SG;Draper, SJ;Simerly, RB
通讯作者：
Simerly, RB
影响因子：
8
作者：
Cheng, Wenwen;Ndoka, Ermelinda;Myers, Martin G., Jr.
通讯作者：
Myers, Martin G., Jr.