MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection.
MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection.
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DOI：
10.1021/acsami.0c14752
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发表时间：
2020-10
影响因子：
9.5
通讯作者：
Jie Yin;Qiuyang Han;Junchuan Zhang;Yunxiu Liu;Xueqi Gan;K. Xie;L. Xie;Yi Deng
中科院分区：
文献类型：
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作者：
Jie Yin;Qiuyang Han;Junchuan Zhang;Yunxiu Liu;Xueqi Gan;K. Xie;L. Xie;Yi Deng
骨肉瘤切除后，癌症复发、术后感染和大量骨丢失的风险仍然威胁着患者的健康。常规治疗依赖于植入矫形材料填充术后骨缺损，但它没有破坏残留肿瘤细胞和阻止细菌侵入的能力。为了应对这一挑战，我们开发了一种新型多功能植入物（SP@MX/GelMA），主要由MXene纳米片，明胶甲基丙烯酸酯（GelMA）水凝胶和生物惰性磺化聚醚醚酮（SP）组成，目的是促进肿瘤细胞死亡，对抗病原菌，促进成骨。由于MXene和聚多巴胺（pDA）的协同光热效应，在808 nm近红外（NIR）照射下，骨肉瘤细胞在多功能涂层上通过热消融被有效杀死。加载妥布霉素（TOB）后，SP@MX-TOB/GelMA植入物对革兰氏阴性/革兰氏阳性细菌显示出强大的抗菌性能。更重要的是，多功能植入物被证明在细胞复制、扩散、碱性磷酸酶活性、钙基质矿化和体内骨整合方面具有上级细胞相容性和促骨生成能力。因此，这种光热控制的多功能植入物不仅能击败骨肉瘤细胞和细菌，而且还能增强成骨性，这对于治疗骨肉瘤切除术后的组织损伤是非常有希望的对策。
After an osteosarcoma resection, the risks of cancer recurrence, postoperative infection, and large bone loss still threaten patients' health. Conventional treatment relies on implanting orthopedic materials to fill bone defects after surgery, but it has no ability of destroying residual tumor cells and preventing bacterial invasion. To tackle this challenge, here, we develop a novel multifunctional implant (SP@MX/GelMA) that mainly consists of MXene nanosheets, gelatin methacrylate (GelMA) hydrogels, and bioinert sulfonated polyetheretherketone (SP) with the purpose of facilitating tumor cell death, combating pathogenic bacteria, and promoting osteogenicity. Because of the synergistic photothermal effects of MXene and polydopamine (pDA), osteosarcoma cells are effectively killed on the multifunctional coatings under 808 nm near-infrared (NIR) irradiation through thermal ablation. After loading tobramycin (TOB), the SP@MX-TOB/GelMA implants display robust antibacterial properties against Gram-negative/Gram-positive bacteria. More importantly, the multifunctional implants are demonstrated to have superior cytocompatibility and osteogenesis-promoting capability in terms of cell replication, spreading, alkaline phosphatase activity, calcium matrix mineralization, and in vivo osseointegration. Accordingly, such photothermally controlled multifunctional implants not only defeat osteosarcoma cells and bacteria but also intensify osteogenicity, which hold a greatly promising countermeasure for curing postoperative tissue lesion from an osteosarcoma excision.