Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.
Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.
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在没有TLR2激活的情况下，穆里达鲁姆呼吸道感染的毒力增强了。
DOI：
10.1371/journal.pone.0020846
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Ingalls RR
中科院分区：
文献类型：
--
作者：
He X;Nair A;Mekasha S;Alroy J;O'Connell CM;Ingalls RR
Chlamydia trachomatis is a common sexually transmitted pathogen and is associated with infant pneumonia. Data from the female mouse model of genital tract chlamydia infection suggests a requirement for TLR2-dependent signaling in the induction of inflammation and oviduct pathology. We hypothesized that the role of TLR2 in moderating mucosal inflammation is site specific. In order to investigate this, we infected mice via the intranasal route with C. muridarum and observed that in the absence of TLR2 activation, mice had more severe disease, higher lung cytokine levels, and an exaggerated influx of neutrophils and T-cells into the lungs. This could not be explained by impaired bacterial clearance as TLR2-deficient mice cleared the infection similar to controls. These data suggest that TLR2 has an anti-inflammatory function in the lung during Chlamydia infection, and that the role of TLR2 in mucosal inflammation varies at different mucosal surfaces.
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影响因子：
4.8
作者：
O'Connell, CM;Ionova, IA;Ingalls, RR
通讯作者：
Ingalls, RR
影响因子：
4.8
作者：
Naiki, Y;Michelsen, KS;Arditi, M
通讯作者：
Arditi, M
影响因子：
6.4
作者：
BARRON, AL;WHITE, HJ;MOSES, EB
通讯作者：
MOSES, EB
DOI：
10.4049/jimmunol.0901465
发表时间：
2009-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chen Q;Davidson TS;Huter EN;Shevach EM
通讯作者：
Shevach EM
影响因子：
5.4
作者：
Rodriguez, Nuria;Wantia, Nina;Miethke, Thomas
通讯作者：
Miethke, Thomas