Cavity optomechanical spring sensing of single molecules.
Cavity optomechanical spring sensing of single molecules.
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DOI：
10.1038/ncomms12311
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发表时间：
2016-07-27
影响因子：
16.6
通讯作者：
Lu T
中科院分区：
文献类型：
--
作者：
Yu W;Jiang WC;Lin Q;Lu T
无标签生物传感是各种健康和安全相关应用的关键功能。微/纳米光子器件非常适合于这一目的，近年来已成为有前途的平台。在这里，我们提出并证明了一种方法，利用高Q相干光机械振荡器中的光学弹簧效应，与传统方法相比，通过数量级大幅提高传感分辨率，使我们能够检测到单个牛血清白蛋白蛋白，其分子量为66 kDa，信噪比为16.8。独特的光学弹簧传感方法开辟了一条独特的途径，不仅能够在个体水平上进行生物分子传感和识别，而且对于依赖于光学腔共振位移的灵敏检测来探测外部物理参数的广泛物理传感应用也具有很大的前景。 单个纳米颗粒或分子的检测对于许多应用是必不可少的。在这里，Yu等人展示了使用具有光机械振荡的光学腔来检测单个牛血清白蛋白，具有研究单个分子的机械特性和相互作用的潜力。
Label-free bio-sensing is a critical functionality underlying a variety of health- and security-related applications. Micro-/nano-photonic devices are well suited for this purpose and have emerged as promising platforms in recent years. Here we propose and demonstrate an approach that utilizes the optical spring effect in a high-Q coherent optomechanical oscillator to dramatically enhance the sensing resolution by orders of magnitude compared with conventional approaches, allowing us to detect single bovine serum albumin proteins with a molecular weight of 66 kDa at a signal-to-noise ratio of 16.8. The unique optical spring sensing approach opens up a distinctive avenue that not only enables biomolecule sensing and recognition at individual level, but is also of great promise for broad physical sensing applications that rely on sensitive detection of optical cavity resonance shift to probe external physical parameters. Detection of a single nanoparticle or molecule is essential for many applications. Here, Yu et al. demonstrate the use of an optical cavity with optomechanical oscillation to detect single bovine serum albumin proteins, with potential for studying mechanical properties and interactions of individual molecules.