Isolation and characterization of naturally occurring subclasses of human peripheral blood T cells with regulatory functions.
Isolation and characterization of naturally occurring subclasses of human peripheral blood T cells with regulatory functions.
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具有调节功能的人外周血 T 细胞天然亚类的分离和表征。
DOI：
10.4049/jimmunol.120.4.1278
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发表时间：
1978
影响因子：
4.4
通讯作者：
S. Schlossman
中科院分区：
文献类型：
--
作者：
A. Strelkauskas;Victoria Schauf;Barry S. Wilson;Leonard Chess;S. Schlossman
通过利用幼年类风湿性关节炎患者自然产生的自身免疫抗体，我们分离出两个独特的T细胞亚群并对其进行功能表征。JRA+ T细胞，即那些从这些患者的血清中鉴定出来的细胞，对异体细胞反应较差，对Con A有反应，但对PHA没有反应，并且不能帮助B细胞合成和分泌Ig。相比之下，JRA- T细胞，即那些未被这些患者血清识别的细胞，对异体细胞反应非常好，对PHA反应良好，但对Con A反应不佳，更有趣的是，可以大大增强B细胞分泌Ig。
By utilizing naturally occurring autoimmune antibodies from patients with juvenile rheumatoid arthritis, we have isolated and functionally characterized two unique subpopulations of T cells. JRA+ T cells, i.e., those identified by sera from these patients, react poorly in response to allogeneic cells, respond to Con A but not PHA, and do not help in the synthesis and secretion of Ig by B cells. In contrast, JRA- T cells, i.e., those not identified by sera from these patients, respond very well to allogeneic cells, proliferate well in response to PHA but not Con A, and more interestingly, can greatly enhance the secretion of Ig by B cells.