Fluorine-18-labeled fluorine gas for synthesis of tracer molecules
Fluorine-18-labeled fluorine gas for synthesis of tracer molecules
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DOI：
10.1016/s0969-8051(97)00078-4
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发表时间：
1997-10-01
影响因子：
3.1
通讯作者：
Solin, O
中科院分区：
文献类型：
--
作者：
Bergman, J;Solin, O
本工作的目的是发展一种生产高比放射性（SA，放射性/质量比）的F-18标记氟气（[F-18]F-2）的方法。由[F-18]F-aq（-）合成了F-18-标记的甲基氟（[F-18] CH_3F），并与载体F-2在惰性氖基质中混合。这些成分在放电中雾化，之后发生重排和F-18与F-19的交换。比放射性高达55 GBq/μ mol的[F-18]F-2可用于正电子发射断层扫描（PET）示踪剂的标记合成。(C)1997年爱思唯尔科学公司
The aim of this work was to develop a method to produce F-18-labeled fluorine gas ([F-18]F-2) with high specific radioactivity (SA, radioactivity/mass-ratio). F-18-Labeled methyl fluoride ([F-18]CH3F) was synthesized from [F-18]F-aq(-) and mixed with carrier F-2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and F-18 for F-19 exchange took place. [F-18]F-2 with a specific radioactivity of up to 55 GBq/mu mol is available for the labeling synthesis of tracers for positron emission tomography (PET). (C) 1997 Elsevier Science Inc.