Expression pattern of adhesion molecules (E-cadherin, α-, β, γ-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis
Expression pattern of adhesion molecules (E-cadherin, α-, β, γ-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis
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DOI：
10.1111/j.1600-0463.2007.apm_524.x
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发表时间：
2007-01-01
期刊：
影响因子：
2.8
通讯作者：
Sauer, Torill
中科院分区：
文献类型：
--
作者：
Park, Daehoon;Karesen, Rolf;Sauer, Torill
细胞间粘附减少与转移的发展有关。本研究探讨细胞间粘附分子（E-钙粘蛋白，（α-，β-，γ-连环蛋白和claudin-7）的表达及其对原发性乳腺癌和相应的腋窝淋巴结转移（ALNM）的生存的影响，并评估它们之间的关联和与临床病理因素。应用免疫组化方法检测了196例原发性浸润性乳腺癌及其淋巴结转移（导管型174例，小叶型22例）组织中粘附分子的表达。使用免疫反应性的强度和比例的半定量评分来评价表达。所有五种粘附蛋白在原发性导管癌中的表达均显着降低，在ALNM中重新表达（p < 0.001）。在单因素和多因素分析中，原发性肿瘤中E-钙粘蛋白的表达是无病生存和无远处转移生存的重要预测因子。因此，在原发性浸润性乳腺癌中异常的E-cadherin表达似乎是预测淋巴结阳性乳腺癌患者生存期较短的独立预后生物标志物。结果表明，异常表达的粘附分子在原发肿瘤与重新表达在相应的淋巴结转移是一个常见的事件，在乳腺导管癌，并可能发挥核心作用，在建立转移。
Reduced intercellular adhesion is implicated in the development of metastasis. This study investigates the expression of intercellular adhesion molecules (E-cadherin, (alpha-, beta-, gamma-catenin and claudin-7) and their influence on survival in primary breast carcinomas and corresponding axillary lymph node metastases (ALNM), and evaluates associations between them and with clinicopathological factors. The expression of adhesion molecules was analyzed immunohistochemically in tissues from 196 patients with primary invasive breast carcinomas and their nodal metastases (174 ductal and 22 lobular types). The expression was evaluated using semi-quantitative scoring of the intensity and proportion of immunoreactivity. All five adhesion proteins showed significantly reduced expression in primary ductal carcinomas with re-expression in ALNM (p < 0.001). In uni- and multivariate analyses, the expression of E-cadherin in the primary tumours was a significant predictor of disease-free survival and distant disease-free survival. Thus, abnormal E-cadherin expression in the primary invasive breast carcinoma seems to be an independent prognostic biomarker in predicting a shorter survival in node-positive breast cancer patients. The results indicate that abnormal expression of the adhesion molecules in the primary tumours with re-expression in corresponding nodal metastases is a common event in breast ductal carcinomas and may play a central role in establishing metastasis.