Prognostic Implications of and Audiometric Evidence for Hearing Fluctuation in Meniere's Disease
Prognostic Implications of and Audiometric Evidence for Hearing Fluctuation in Meniere's Disease
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DOI：
10.1002/lary.25579
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发表时间：
2015-12-01
期刊：
影响因子：
2.6
通讯作者：
Derebery, M. Jennifer
中科院分区：
文献类型：
--
作者：
Hoa, Michael;Friedman, Rick A.;Derebery, M. Jennifer
目的/假设：1）通过评估梅尼埃病过程中听力波动的范围和发生率，建立显著听力波动的标准; 2）确定是否存在听力学证据来支持梅尼埃病是一种涉及整个耳蜗的病理生理过程的概念; 3）提出梅尼埃病患者初始听力波动的预后意义。研究设计：回顾性病例系列分析：方法：前瞻性收集了488例符合1995年美国耳鼻咽喉头颈外科学会梅尼埃病诊断标准的患者的听力测定数据（2个队列：分别在2002年4月至2003年7月和2010年1月至12月期间首次就诊的341例和146例患者）。根据显著听力波动的几种定义，在任何两次连续评估之间，听力变化被分类为“相同”、“更差”或“更好”。初始听力波动的关系，未来的听力波动和未来的听力lossedevaluated.Results：听力波动是明显的梅尼埃病患者的异质性听力随访，这些听力波动的特点，包括平均发病率，进行了描述。测听数据表明，梅尼埃病的低频和高频阈值变化之间存在高度一致性。最初的听力波动与未来和更频繁的听力波动的发生有关。结论：了解听力波动的范围建立了一个基础，用于确定听力阈值评估未来的治疗试验，旨在预防梅尼埃病的听力损失。这方面的知识也将告知咨询针对患者诊断梅尼埃病。
Objectives/Hypothesis: 1) To establish criteria for significant hearing fluctuation by assessing the range and occurrence of hearing fluctuations over the course of Meniere's disease; 2) to determine if audiometric evidence exists to support the notion that Meniere's disease is a pathophysiologic process involving the whole cochlea; and 3) to suggest prognostic implications for initial hearing fluctuation in patients with Meniere's disease.Study Design: Retrospective case series review.Methods: A total of 488 patients diagnosed by 1995 American Academy of Otolaryngology-Head and Neck Surgery Meniere's disease criteria for whom audiometric data were prospectively collected (2 cohorts: 341 and 146 patients initially seen between April 2002 to July 2003 and between January to December 2010, respectively). Based on several definitions for significant hearing fluctuation, change in hearing was categorized as "same," "worse," or "better" between any two consecutive evaluations. The relationship of initial hearing fluctuation to future hearing fluctuation and future hearing loss was evaluated.Results: Hearing fluctuation was evident in Meniere's disease patients with heterogeneous audiometric follow-up; and the characteristics of these hearing fluctuations, including the mean incidence, is described. Audiometric data suggests that there is a high congruence in Meniere's disease between changes in low-and high-frequency thresholds. Initial hearing fluctuation is associated with the occurrence of future and more frequent hearing fluctuations.Conclusion: Understanding the range of hearing fluctuations establishes a basis for determining audiometric thresholds used in evaluating future therapeutic trials aimed at the prevention of hearing loss in Meniere's disease. This knowledge will also inform the counseling directed toward patients diagnosed with Meniere's disease.