Immunomodulation by probiotic lactobacilli in layer- and meat-type chickens
Immunomodulation by probiotic lactobacilli in layer- and meat-type chickens
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DOI：
10.1080/00071660410001730851
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发表时间：
2004-06-01
影响因子：
2
通讯作者：
Boersma, WJA
中科院分区：
文献类型：
--
作者：
Koenen, ME;Kramer, J;Boersma, WJA
1.本试验的目的是评价所选益生菌菌株对蛋鸡和肉鸡的免疫调节作用是否不同.通过细胞增殖、沙门氏菌在肠道和脾脏白细胞中的进入和存活、免疫球蛋白同种型和特异性免疫球蛋白滴度等实验，研究了沙门氏菌的体液和细胞特异性和非特异性免疫应答.研究了两种不同的喂养方式（短时间喂养和连续喂养）和乳酸杆菌给药剂量的影响.所评价的菌株对蛋鸡和肉鸡的免疫系统具有调节作用.在肉用型鸡中，乳杆菌在幼鸡（3周龄以下）时具有刺激作用，且剂量相对较高;而在蛋鸡中，较低的有效剂量和间断给药也有效.免疫益生菌乳酸杆菌可以对蛋鸡和肉类品系鸡的体液和细胞免疫应答产生积极影响，但需要优化使用的益生菌菌株、动物的年龄和乳酸杆菌的有效剂量。
1. The aim of the experiments was to evaluate whether selected probiotic lactobacillus strains have different immunomodulating effects in layer- and meat-type strain chickens.2. Humoral and cellular specific and non-specific immune responses were studied by experiments on cellular proliferation, entry and survival of Salmonella bacteria in gut and spleen leukocytes, immunoglobulin isotypes and specific immunoglobulin titres.3. The effects of two different feeding regimes (short and continuous feeding) and doses for administration of lactobacilli were studied.4. The lactobacillus strains that were evaluated showed modulating effects on the immune system of layer- and meat-type chickens.5. In meat-type strain chickens the lactobacilli had a stimulating effect when the chickens were young (up to 3 weeks) and the dose was relatively high, whereas in layer- type chickens a lower effective dose and discontinuous administration was also effective.6. Immunoprobiotic lactobacilli can have a positive effect on humoral and cellular immune responses in layer- and meat-type strain chickens, but the lactobacillus strain to be used, the age of the animals and effective dose of lactobacilli to be administered need to be optimised.