Nuclear receptors in renal health and disease.
Nuclear receptors in renal health and disease.
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DOI：
10.1016/j.ebiom.2022.103855
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发表时间：
2022-03
期刊：
影响因子：
11.1
通讯作者：
Zhang XY
中科院分区：
文献类型：
--
作者：
Luan ZL;Zhang C;Ming WH;Huang YZ;Guan YF;Zhang XY
作为医疗保健系统的主要社会和经济负担，肾脏疾病导致全球死亡人数不断增加。对肾脏疾病的病因、发生和进展的潜在机制的更深入理解可能有助于确定潜在的治疗靶点。核受体（nuclear receptor，NRs）是一个配体依赖性转录因子超家族，对维持正常肾功能至关重要，其功能障碍与多种肾脏疾病有关。越来越多的证据表明，NR的配体保护患者免受肾缺血/再灌注（I/R）损伤、药物诱导的急性肾损伤（阿基）、糖尿病肾病（DN）、肾纤维化和肾癌。在过去的十年中，NR配体的临床应用已经取得了一些突破。本文综述了几个重要的NR在肾脏生理和病理生理的认识，并讨论了最近的发现和NR配体在肾脏疾病的管理应用。
As a major social and economic burden for the healthcare system, kidney diseases contribute to the constant increase of worldwide deaths. A deeper understanding of the underlying mechanisms governing the etiology, development and progression of kidney diseases may help to identify potential therapeutic targets. As a superfamily of ligand-dependent transcription factors, nuclear receptors (NRs) are critical for the maintenance of normal renal function and their dysfunction is associated with a variety of kidney diseases. Increasing evidence suggests that ligands for NRs protect patients from renal ischemia/reperfusion (I/R) injury, drug-induced acute kidney injury (AKI), diabetic nephropathy (DN), renal fibrosis and kidney cancers. In the past decade, some breakthroughs have been made for the translation of NR ligands into clinical use. This review summarizes the current understanding of several important NRs in renal physiology and pathophysiology and discusses recent findings and applications of NR ligands in the management of kidney diseases.
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