Screening for predementia AD Time-dependent operating characteristics of episodic memory tests
Screening for predementia AD Time-dependent operating characteristics of episodic memory tests
复制标题
DOI：
10.1212/wnl.0b013e31828ab2c9
复制
发表时间：
2013-04-01
期刊：
影响因子：
9.9
通讯作者：
Lipton, Richard B.
中科院分区：
文献类型：
--
作者：
Derby, Carol A.;Burns, Leah C.;Lipton, Richard B.
目的：来自爱因斯坦衰老研究（EAS）的数据被用来前瞻性地评估自由和线索选择性回忆测试的自由回忆分数（FCSRT-FR）和逻辑记忆I立即回忆（LM-IR）子测试的韦氏记忆量表-修订的预测事件阿尔茨海默病（AD）痴呆的个体之间的基于社区的队列与记忆投诉。分析包括854名参与者，年龄>= 70岁，最初没有痴呆症，并有记忆投诉。每年完成临床评估，并使用标准标准诊断AD痴呆（n = 86例;平均随访4.1年）。结果：对于有记忆障碍的AD患者，FCSRT-FR比LM-IR具有更好的操作特征，APOE β 4状态、年龄和受教育程度对分界点没有影响;然而，APOE epsilon 4阳性个体的阳性预测值更高。结论：对于2-4年的随访间隔，FCSRT-FR比LM-IR更能预测患有记忆投诉的个体是否会发展为AD事件。APOE β 4状态提高阳性预测值，但不影响最佳切割的选择。神经病学（R）2013;80：1307-1314
Objective: Data from the Einstein Aging Study (EAS) were used to prospectively evaluate the free recall score from the Free and Cued Selective Reminding Test (FCSRT-FR) and Logical Memory I immediate recall (LM-IR) subtest of the Wechsler Memory Scale-Revised for prediction of incident Alzheimer disease (AD) dementia among individuals from a community-based cohort with memory complaints.Methods: Analyses included 854 participants, age >= 70 years, who initially had no dementia, and had memory complaints. Clinic evaluations were completed annually and AD dementia was diagnosed using standard criteria (n = 86 cases; average follow-up 4.1 years). Time-dependent receiver operating characteristic analysis was used to evaluate the prognostic ability of FCSRT-FR and LM-IR for incident AD over various durations of follow-up.Results: For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR. APOE epsilon 4 status, age, and education did not affect cut points; however, positive predictive values were higher among APOE epsilon 4-positive individuals.Conclusions: For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD. APOE epsilon 4 status improves positive predictive value, but does not affect the choice of optimal cuts. Neurology (R) 2013;80:1307-1314