TNF and sTNFR1/2 plasma levels in ALS patients
TNF and sTNFR1/2 plasma levels in ALS patients
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DOI：
10.1016/j.jneuroim.2007.10.028
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Ceroni, Mauro
中科院分区：
文献类型：
--
作者：
Cereda, Cristina;Baiocchi, Chiara;Ceroni, Mauro
免疫系统参与了肌萎缩侧索硬化症(ALS)的发病机制。在这项研究中，与正常人相比，散发性ALS患者血浆中的肿瘤坏死因子-α及其可溶性受体，即肿瘤坏死因子-1和肿瘤坏死因子-2的水平显著升高。对肿瘤坏死因子-α、肿瘤坏死因子-1和肿瘤坏死因子-2等位基因的遗传分析显示，患者组和对照组的等位基因和基因型频率无统计学差异。这些数据表明，免疫系统参与了对未知细胞内信号的反应。(C)2007 Elsevier B.V.保留所有权利。
The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals. (C) 2007 Elsevier B.V. All rights reserved.