Hyaluronic acid functionalized biodegradable mesoporous silica nanocomposites for efficient photothermal and chemotherapy in breast cancer
Hyaluronic acid functionalized biodegradable mesoporous silica nanocomposites for efficient photothermal and chemotherapy in breast cancer
复制标题
透明质酸功能化可生物降解介孔二氧化硅纳米复合材料用于乳腺癌的高效光热和化疗
DOI：
10.1088/1361-6528/abda74
复制
发表时间：
2021-04-16
期刊：
影响因子：
3.5
通讯作者：
Zhang, Chaolin
中科院分区：
文献类型：
--
作者：
Zhan, Wenhua;Li, Hanrui;Zhang, Chaolin
化疗是乳腺癌的常规治疗方法之一，但药物毒副作用严重限制了其临床应用。光热疗法已成为一种有前途的方法，与化疗相结合，可以更好地治疗乳腺癌。在此背景下，开发了一种可生物降解的介孔二氧化硅纳米粒子（bMSN NPs）系统，用于负载阿霉素（DOX）和IR780，有望应用于乳腺癌的治疗。 IR780通过疏水吸附被封装在bMSN NPs的孔内，而DOX通过透明质酸静电吸附在bMSN NPs的表面，形成bMID NPs。利用透射电镜、荧光光谱和紫外吸收光谱证明IR780的成功封装和DOX的负载。体外实验表明bMID NPs对乳腺癌细胞具有优异的治疗效果。体内荧光成像结果表明bMID NPs可以在肿瘤部位逐渐积累并实现体内长期循环和持续药物释放。此外，bMID NPs 在乳腺癌小鼠模型中具有明显的抗肿瘤作用，从而发展成为乳腺癌治疗的有效平台。
Chemotherapy is one of conventional treatment methods for breast cancer, but drug toxicity and side effects have severely limited its clinical applications. Photothermal therapy has emerged as a promising method that, upon combination with chemotherapy, can better treat breast cancer. In this context, a biodegradable mesoporous silica nanoparticle (bMSN NPs) system was developed for loading doxorubicin (DOX) and IR780, to be potentially applied in the treatment of breast cancer. IR780 is encapsulated in the pores of bMSN NPs by hydrophobic adsorption, while DOX is adsorbed on the surface of the bMSN NPs by hyaluronic acid electrostatically, to form the bMID NPs. Transmission electron microscopy, fluorescence spectrum and UV absorption spectrum are used to prove the successful encapsulation of IR780 and the loading of DOX. In vitro experiments have shown bMID NPs present an excellent therapeutic effect on breast cancer cells. In vivo fluorescence imaging results have indicated that bMID NPs can accumulate in tumor sites gradually and achieve in vivo long-term circulation and continuous drug release. Furthermore, bMID NPs have provided obvious antitumor effects in breast cancer mouse models, thus evolving as an efficient platform for breast cancer therapy.