Antitumor and Immunostimulatory Effects of Residual Powder from Barley-Shochu Distillation Remnants
Antitumor and Immunostimulatory Effects of Residual Powder from Barley-Shochu Distillation Remnants
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DOI：
10.1248/jhs.54.287
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发表时间：
2008-06
影响因子：
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通讯作者：
K. Funamoto;Y. Komizu;H. Ichihara;O. Tanoue;K. Goto;R. Ueoka
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文献类型：
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作者：
K. Funamoto;Y. Komizu;H. Ichihara;O. Tanoue;K. Goto;R. Ueoka
从环境保护和生物质的角度来看，开发有效利用烧酒蒸馏残渣的方法是可取的。在这项研究中，我们研究了粉末的抑制作用，本文研究了从大麦烧酒蒸馏残渣中提取的大麦粉对多种肿瘤细胞的体外抑制作用和体内免疫刺激作用，并在体外对人肺肿瘤细胞的生长有明显的抑制作用，同时沿着凋亡诱导作用。大麦粉在体内可诱导正常大鼠血清IFN-γ的产生，并提高自然杀伤细胞（NK）活性。对正常大鼠尾静脉给药，大麦粉无急性毒性。首次发现大麦粉不仅具有抗肿瘤作用，而且具有免疫刺激作用。
The development of effective utilization methods of Shochu distillation remnants is desirable from the viewpoint of environmental protection and biomass. In this study, we examined inhibitory effects of the powder (barleypowder) obtained from the barley-Shochu distillation remnants on the various tumor cells in vitro and immunostimulation effect in vivo .R emarkable inhibitory effects on the growth of human lung tumor cells along with the induction of apoptosis were obtained for barley-powder in vitro .O nt he other hand, the barley-powder induced the production of serum Interferon (IFN)-γ for normal rats in vivo ,a nd increased natural killer (NK) activity. Furthermore, the barley-powder showed no acute toxicity in the tail vein administration to normal rats. It was found that the barley-powder had not only an antitumor effect but also an immunostimulation effect for the first time.