Role of calcium during Toxoplasma gondii invasion and egress
Role of calcium during Toxoplasma gondii invasion and egress
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DOI：
10.1016/j.ijpara.2003.11.017
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发表时间：
2004-03-09
影响因子：
4
通讯作者：
Boothroyd, JC
中科院分区：
文献类型：
--
作者：
Arrizabalaga, G;Boothroyd, JC
钙是一种普遍存在的信号分子，参与真核细胞的大量细胞过程。例如，在专性细胞内寄生虫刚地弓形虫中，钙浓度的升高与显著的形态改变、参与宿主细胞入侵和快速离开宿主细胞的蛋白质分泌有关。最近的研究结果表明，从寄生虫的细胞内池释放的钙是必要和充分的，以诱导一些至关重要的入侵和退出事件。此外，乙醇，一种强大的入侵相关事件的诱导剂，也可以诱导宿主细胞的快速退出，这表明在入侵和退出过程中可能涉及钙释放的共同机制。(C) 2004澳大利亚寄生虫学学会Elsevier Ltd.出版。版权所有。
Calcium is a ubiquitous signalling molecule involved in a large number of cellular processes in eukaryotic cells. In the obligate intracellular parasite, Toxoplasma gondii, for example, a rise in calcium concentration is associated with significant morphological changes, secretion of proteins involved in host cell invasion and rapid egress from the host cell. Recent findings indicate that calcium released from the parasite's intracellular pools is necessary and sufficient to induce some of the events critical for invasion and egress. In addition, ethanol, a powerful inducer of invasion-related events, is shown here to also induce rapid egress from the host cell, indicating that a common mechanism for calcium release might be involved during both invasion and egress. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.