Cohort Profile: The Cardiovascular Risk in Young Finns Study
Cohort Profile: The Cardiovascular Risk in Young Finns Study
复制标题
DOI：
10.1093/ije/dym225
复制
发表时间：
2008-12-01
影响因子：
7.7
通讯作者：
Viikari, Jorma S. A.
中科院分区：
文献类型：
--
作者：
Raitakari, Olli T.;Juonala, Markus;Viikari, Jorma S. A.
在芬兰，冠心病（CHD）的发病率在1960年代和1970年代非常高。1与这种高发病率相一致的是，七国研究表明，芬兰人的血清胆固醇水平也是1960年代被调查国家中最高的。[2]由于几项研究表明动脉粥样硬化过程在生命早期就开始了，并且雅阁组织1978年的建议3指出，应该开始评估儿童动脉粥样硬化前体的研究，因此，20世纪70年代末，芬兰启动了一项研究青年心血管风险的计划。4-6芬兰年轻人心血管风险研究是由五所大学医学院（即赫尔辛基、库奥皮奥、欧卢、坦佩雷和图尔库）和芬兰其他几个机构合作开展的。目的是研究该国不同地区不同年龄段儿童和青少年的冠心病危险因素及其决定因素。1978年（N1/4 264，8岁）和1979年（N1/4 634，3岁、12岁和17岁）进行了两项试点研究。第一个主要的横断面（基线）研究于1980年进行。基线研究包括3596名3、6、9、12、15和18岁的儿童和青少年。8在1980年至1992年期间，每隔3年对这些群体进行一次跟踪调查。芬兰青年心血管风险研究的最近一次审查是在2001年进行的，当时的参与者是24-39岁的年轻人。在撰写本文时，正在进行为期27年（即，当受试者年龄为30-45岁时，自研究开始后的27年）的随访实地研究，并将于2008年初完成。
In Finland, coronary heart disease (CHD) incidence was very high in the 1960s and 1970s. 1 In line with this high incidence, the Seven Countries Study showed that the level of serum cholesterol in Finns was also the highest among the investigated countries in the 1960s. 2 Because several studies indicated that the atherosclerotic process starts early in life, and in accord with the World Health Organization Recommendation of 19783 which stated that studies assessing atherosclerosis precursors in children should be initiated, a program was launched in Finland in the late 1970s to study cardiovascular risk in the youth. 4–6 The Cardiovascular Risk in Young Finns Study was designed as a collaborative effort between five university departments of medical schools (ie in Helsinki, Kuopio, Oulu, Tampere and Turku) and several other institutions in Finland. The aim was to study the levels of CHD risk factors and their determinants in children and adolescents of various ages in different parts of the country. Two pilot studies were carried out in 1978 (N ¼ 264, age 8 years) and in 1979 (N ¼ 634, aged 3, 12 and 17 years). 6, 7 The first main cross-sectional (baseline) study was performed in 1980. The baseline study included 3596 children and adolescents aged 3, 6, 9, 12, 15 and 18 years. 8 Between 1980 and 1992, these cohorts were followed up at 3-year intervals. The latest examination of the Cardiovascular Risk in Young Finns Study was performed in 2001, when the participants were young adults, aged 24–39 years. At the time of writing, the 27-year (ie 27 years since the start of the study when the participants are aged 30–45 years) follow-up field studies are being conducted, and will be completed in the beginning of 2008.