Papillomavirus is resistant to desiccation
Papillomavirus is resistant to desiccation
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DOI：
10.1086/516515
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发表时间：
1997-10-01
影响因子：
6.4
通讯作者：
Schiller, JT
中科院分区：
文献类型：
--
作者：
Roden, RBS;Lowy, DR;Schiller, JT
有强有力的流行病学证据表明高危生殖器人类乳头瘤病毒(HPV)类型的性传播。然而，目前尚不清楚感染是否也可能通过融合基因间接传播。为了评估这种可能性，对干燥后的体外传染性进行了比较，其中伪型HPV-16病毒粒子是高危型生殖器HPV的模型，牛乳头瘤病毒1型(BPV-1)是一种已知通过融合基因传播的乳头瘤病毒。两种病毒在细胞提取液中对干燥的抗性相似，在室温下脱水1、3和7d时，其感染力分别保持在100%、50%和30%左右。细胞提取物中的假型HPV-16和BPV经高压灭菌处理后完全灭活，对70%乙醇敏感，但对EDTA或56℃孵育1h耐受，提示进一步研究高危生殖器HPV通过融合体非性传播是有必要的。
There is strong epidemiologic evidence for sexual transmission of high-risk genital human papillomavirus (HPV) types. However, it is unclear if infection may also be transmitted indirectly via fomites. To assess this possibility, the in vitro infectivity after desiccation was compared for pseudotype HPV-16 virions, a model for high-risk type genital HPV, and bovine papillomavirus type 1 (BPV-1), a papillomavirus known to be transmitted via fomites. The 2 viruses had similar resistance to desiccation in cell extracts, retaining similar to 100%, 50%, and 30% of infectivity when dehydrated for 1, 3, and 7 days, respectively, at room temperature. Pseudotype HPV-16 and BPV in cell extracts were completely inactivated by autoclave treatment and susceptible to 70% ethanol but were resistant to EDTA or incubation at 56 degrees C for 1 h. The data suggest that further study of nonsexual spread of high-risk genital HPV via fomites is warranted.