Wearable, nanofiber-based microfluidic systems with integrated electrochemical and colorimetric sensing arrays for multiplex sweat analysis
Wearable, nanofiber-based microfluidic systems with integrated electrochemical and colorimetric sensing arrays for multiplex sweat analysis
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DOI：
10.1016/j.cej.2022.140248
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发表时间：
2022-11-12
影响因子：
15.1
通讯作者：
Li, Yingchun
中科院分区：
文献类型：
--
作者：
Mei, Xuecui;Yang, Jiao;Li, Yingchun
用于汗液分析的可穿戴微流体传感器对于人体健康的非侵入性监测是非常期望的。然而，先前报道的用于汗液分析的中空结构的微流体网络难以避免由于可溶性化学试剂的扩散而对皮肤的潜在化学伤害，并且不能最小化由皮肤分泌的污染物引起的传感器的损害。还需要使用替代技术的低成本微流体传感器来实现廉价的装置。此外，将多模态传感器整合到一个微流体装置中，同时保持其灵活性和小型化仍然具有挑战性。在此，我们报告了一种基于纳米纤维的微流控分析系统（NFMAS），用于原位汗液监测。纳米纤维作为微流体网络构建的关键元素，可以自发地捕获和路由汗液。双模式传感阵列嵌入到微流体网络中，以保护每个传感单元免受任何干扰。NFMAS可以保形和无害地结合到皮肤表面，并表现出良好的性能，同时定量葡萄糖，乳酸，pH值，Cl-和尿素的电化学和比色模式。人体研究表明，NFMAS可以在体育锻炼期间提供与汗液化学相关的连续多模态信息，揭示了在实时监测人体健康方面的应用前景。
Wearable microfluidic sensors for sweat analysis are highly desirable for noninvasive monitoring of human health. However, previously reported hollow-structured microfluidic networks for sweat analysis have difficulty in avoiding the potential chemical harm to skin due to diffusion of soluble chemical reagents and cannot minimize the impairment of sensors caused by contaminants secreted from skin. Low-cost microfluidic sensors using alternative techniques are also required to enable inexpensive devices. Besides, incorporating multimodal sensors into one microfluidic device while maintaining its flexibility and miniaturization still possesses challenges. Herein, we reported a nanofiber-based microfluidic analysis system (NFMAS) for in situ sweat monitoring. Nanofibers served as the key element for microfluidic networks construction to spontaneously capture and route sweat. Dual-mode sensing arrays were embedded into the microfluidic network to protect each sensing unit from any disturbance. The NFMAS can conformally and innocuously bond to the skin surface and exhibited good performance in simultaneous quantification of glucose, lactate, pH, Cl- and urea by both electrochemistry and colorimetry modes. Human studies demonstrated that the NFMAS can provide continuous, multimodal information associated with sweat chemistry during physical exercise, revealing promising applications in real-time monitoring of human health.