Role of Neuronal Synchrony in the Generation of Evoked EEG/MEG Responses
Role of Neuronal Synchrony in the Generation of Evoked EEG/MEG Responses
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DOI：
10.1152/jn.00138.2010
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发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
Curio, Gabriel
中科院分区：
文献类型：
--
作者：
Telenczuk, Bartosz;Nikulin, Vadim V.;Curio, Gabriel
Telenczuk B、Nikulin VV、Curio G.神经元同步性在诱发EEG/MEG反应产生中的作用。J Neurophysiol 104：3557-3567，2010.首次发表于2010年10月13日; doi：10.1152/jn.00138.2010。诱发EEG/MEG反应是人类大脑中感知和认知活动的主要实时测量，但其神经元发生器机制尚未完全理解。争论已经提出了赞成“相位重置”的持续振荡或“附加能量”的模型。而不是提倡一个或另一个模型，在这里，我们从理论上表明，这两个生成机制之间的区别可能是不可能的，如果仅仅基于宏观EEG/MEG记录。使用数学建模，我们表明，多个振荡神经元（微观）源的EEG/MEG的同时相位复位可以产生诱发反应的协议，“附加能量”和“相位复位”模型。通过改变多个微观源之间的同步强度，我们观察到两个模型之间的平滑过渡。因此，由于在非侵入性EEG/MEG研究中通常无法获得关于微观集合同步强度的精确知识，因此原则上无法区分宏观诱发反应的两种机制。
Telenczuk B, Nikulin VV, Curio G. Role of neuronal synchrony in the generation of evoked EEG/MEG responses. J Neurophysiol 104: 3557-3567, 2010. First published October 13, 2010; doi:10.1152/jn.00138.2010. Evoked EEG/MEG responses are a primary real-time measure of perceptual and cognitive activity in the human brain, but their neuronal generator mechanisms are not yet fully understood. Arguments have been put forward in favor of either "phase-reset" of ongoing oscillations or "added-energy" models. Instead of advocating for one or the other model, here we show theoretically that the differentiation between these two generation mechanisms might not be possible if based solely on macroscopic EEG/MEG recordings. Using mathematical modeling, we show that a simultaneous phase reset of multiple oscillating neuronal (microscopic) sources contributing to EEG/MEG can produce evoked responses in agreement with both, the "added-energy" and the "phase-reset" model. We observe a smooth transition between the two models by just varying the strength of synchronization between the multiple microscopic sources. Consequently, because precise knowledge about the strength of microscopic ensemble synchronization is commonly not available in noninvasive EEG/MEG studies, they cannot, in principle, differentiate between the two mechanisms for macroscopic-evoked responses.