Considerations on COVID-19 pregnancy: a cases series during outbreak in Bergamo Province, North Italy
Considerations on COVID-19 pregnancy: a cases series during outbreak in Bergamo Province, North Italy
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DOI：
10.1080/14767058.2020.1791817
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发表时间：
2020-07-14
影响因子：
1.8
通讯作者：
Ciammella, Massimo
中科院分区：
文献类型：
--
作者：
Algeri, Paola;Stagnati, Valentina;Ciammella, Massimo
背景新冠肺炎在全球范围内迅速传播，严重的并发症影响到特别是老年人和弱势群体。到目前为止，文献中关于新冠肺炎怀孕的报道较少。方法对妊娠合并新冠肺炎的病例进行分析。所有病例都是在意大利塞里亚特的博洛尼尼医院确诊的。提出这些病例是为了阐明新冠肺炎在怀孕期间发生的特征。结果4例孕妇在孕期或产后即刻出现新冠肺炎症状。所有病例均经口咽拭子检查确诊。所有患者在诊断时都表现为发热和低饱和度。一名患者在确诊后被转移到第三转诊中心，并在第二天因临床情况恶化而分娩。在其他三例中，入院时记录了双侧肺炎。大多数病例采用了抗血栓治疗。没有新生儿感染病例的报告。随访2个月，所有患者均存活，3例无症状，1例出现神经系统并发症。另有一例因新冠肺炎可疑而被描述，但口咽拭子未证实。结论孕妇外周神经系统可受到影响。无经胎盘通过的病例报告。拭子可能有助于诊断。抗血栓治疗可能在新冠肺炎阳性病程中发挥作用，对孕妇也有作用。
Background COVID-19 has rapidly spread worldwide, with severe complications affecting particularly elderly and compromised subjects. Less information about COVID-19 in pregnancy has been reported so far in the literature. Methods Case series on pregnancies complicated by COVID-19. All cases were diagnosed at Bolognini Hospital, Seriate, Italy. These cases are presented to clarify the features of COVID-19 occurring in pregnancy. Results Four women had symptoms of COVID-19 during pregnancy or immediately after delivery. All cases were confirmed by oropharyngeal swab. All patients presented with fever and low saturation levels at the diagnosis. One case was transferred after diagnosis to a tertiary referral center and delivered the day after for worsening clinical conditions. In the other three cases, bilateral pneumonia was documented at the admission. Antithrombotic therapy was used in most cases. No cases of the infected neonate was reported. At 2 month follow-up, all patients were alive, three were asymptomatic while one presented neurological complication. One more case was described because suspicious for COVID-19, however, it was not confirmed by oropharyngeal swab. Conclusions In pregnant women, the peripheral nervous system could be affected. No case of trans-placental passage was reported. The swab could be helpful in diagnosis. The antithrombotic therapy could play a role in the positive course of COVID-19 also in pregnant women.