TMPRSS2-ERG Gene Fusion Prevalence and Class Are Significantly Different in Prostate Cancer of Caucasian, African-American and Japanese Patients
TMPRSS2-ERG Gene Fusion Prevalence and Class Are Significantly Different in Prostate Cancer of Caucasian, African-American and Japanese Patients
复制标题
DOI：
10.1002/pros.21265
复制
发表时间：
2011-04-01
期刊：
影响因子：
2.8
通讯作者：
Zhou, Ming
中科院分区：
文献类型：
--
作者：
Magi-Galluzzi, Cristina;Tsusuki, Toyonori;Zhou, Ming
背景前列腺癌（PCa）的患病率和死亡率在不同种族群体之间存在显著差异。潜在的遗传学还不太清楚。TMPRSS 2-ERG融合是PCa中常见的复发性染色体畸变，但未在不同种族群体中进行研究。我们研究了白种人、非裔美国人和日本人前列腺癌中TMPRSS 2-ERG基因融合的患病率和类型。采用荧光原位杂交技术对42例高加索人、64例非裔美国人和44例日本患者行根治性前列腺切除术（RP）后的前列腺癌组织微阵列进行ERG基因分离的TMPRSS 2-ERG融合研究。50%（21/42）的白人、31.3%（20/64）的非洲裔美国人和15.9%（7/44）的日本人存在TMPRSS 2-ERG基因融合（P = 0.003）。通过易位、缺失或两者的基因融合在高加索人中分别为61.9%（13/21）、38.1%（8/21）和0%（0/21），在非洲裔美国人中分别为20%（4/20）、60%（12/20）和20%（4/20），在非裔美国人中分别为71.4%（5/7）、28.6%（2/7）、日本患者为0%（0/7）（P = 0.02）。多因素分析显示TMPRSS 2-ERG基因融合与种族相关（P = 0.03），与病理分期轻微相关（P = 0.06），而与年龄、术前PSA水平和Gleason评分等临床病理参数无关。TMPRSS 2-ERG的患病率和分类在白人、非洲裔美国人和日本患者的PCa中存在显著差异。未来对TMPRSS 2-ERG基因融合相关分子通路的研究可能会揭示不同种族人群中PCa患病率和死亡率的差异，并有助于设计更好的预防和治疗策略。前列腺71：489-497，2011年。(C)2010 Wiley-Liss，Inc.
BACKGROUND. Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients.MATERIALS AND METHODS. A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart.RESULTS. TMPRSS2-ERG gene fusion was present in 50% (21/42) of Caucasians, 31.3% (20/64) of African-Americans, and 15.9% (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9% (13/21), 38.1% (8/21), and 0% (0/21) in Caucasians, 20% (4/20), 60% (12/20), and 20% (4/20) in African-Americans, and 71.4% (5/7), 28.6% (2/7), and 0% (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score.CONCLUSIONS. The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 71: 489-497, 2011. (C) 2010 Wiley-Liss, Inc.