LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis
LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis
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DOI：
10.1080/21691401.2019.1577883
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发表时间：
2019-01-01
影响因子：
5.8
通讯作者：
Yang, Jun
中科院分区：
文献类型：
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作者：
Gao, Fangyuan;Feng, Jing;Yang, Jun
长链非编码RNA（lncRNA）已被鉴定为肿瘤发生中的关键参与者。以往的研究表明lncRNA SBF 2-AS 1参与了肿瘤的进展。然而，SBF 2-AS 1在宫颈癌（CC）中的作用和潜在机制仍不清楚。在本研究中，我们的数据表明，SBF 2-AS 1的表达显着增加，在CC。SBF 2-AS 1高表达与CC患者的FIGO分期和淋巴结转移有关。功能测定显示SBF 2-AS 1抑制剂在体外和体内均能显著抑制CC细胞增殖。从机制上讲，我们发现SBF 2-AS 1上调抑制了miR-361- 5 p的活性，并导致FOXM 1在CC细胞中过表达。此外，我们发现miR-361- 5 p抑制剂可以挽救SBF 2-AS 1抑制对CC细胞增殖的影响。综上所述，我们证明SBF 2-AS 1/miR-361- 5 p/FOXM 1轴可能在CC进展中起重要作用。SBF 2-AS 1可能成为CC治疗的潜在靶点。
Long non-coding RNAs (lncRNAs) have been identified as critical players in tumorigenesis. Previous studies revealed that lncRNA SBF2-AS1 was involved in tumor progression. However, the role and underlying mechanism of SBF2-AS1 in cervical cancer (CC) remain unknown. In the present study, our data showed that SBF2-AS1 expression was significantly increased in CC. High SBF2-AS1 expression was associated with advanced FIGO stage and lymph node metastasis of CC patients. Function assays showed that SBF2-AS1 inhibition significantly reduced CC cells proliferation both in vitro and in vivo. Mechanistically, we showed that SBF2-AS1 upregulation restrained the activity of miR-361-5p and led to overexpression of FOXM1 in CC cells. Furthermore, we found that miR-361-5p inhibitors could rescue the effects of SBF2-AS1 inhibition on CC cells proliferation. Taken together, we demonstrated that the SBF2-AS1/miR-361-5p/FOXM1 axis might play an important role in CC progression. SBF2-AS1 might serve as a potential therapeutic target for CC treatment.