Regulation of Interleukin-17 Production
Regulation of Interleukin-17 Production
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IL-17 产生的调节
DOI：
10.1007/978-94-024-0921-5_7
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Ma, Xiaojing
中科院分区：
文献类型：
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作者：
Dong, Wenjuan;Ma, Xiaojing
天然免疫是宿主抵抗细胞外感染的第一道防线。及时启动对入侵病原体的炎症反应赋予宿主预防、限制和消除微生物的能力，并进一步触发适应性免疫以提供病原体的延长根除以及长期保护宿主免受复发感染。在这个过程中，需要各种类型的细胞因子来进行有效的免疫应答，白细胞介素17（IL-17）就是其中之一。IL-17细胞因子家族在先天性免疫应答和适应性免疫应答之间起桥梁作用，并在确定Th 17细胞谱系分化和功能方面发挥重要作用。Th 17细胞在保护宿主抵抗细胞外病原体以及促进自身免疫性疾病的炎症病理学方面具有关键作用。在不同水平上严格调节IL-17家族的细胞因子，确保适当控制其形成免疫应答的能力。本章介绍了IL-17研究领域的最新进展，以了解IL-17家族细胞因子表达和信号转导的调控机制。IL-17 A（IL-17）是该家族中研究最充分的成员，而关于其他成员的信息相对粗略。因此，我们主要关注IL-17 A的研究。
Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection of the host from recurrent infections. During this process, various types of cytokines are required for efficient immune responses, and interleukin 17 (IL-17) is one of them. The IL-17 family of cytokines bridges innate and adaptive immune responses and play an essential role in defining the Th17 cell lineage differentiation and function. Th17 cells have pivotal roles in protecting the host against extracellular pathogens as well as in promoting inflammatory pathology in autoimmune diseases. Strict regulation of the IL-17 family of cytokines at different levels ensures appropriate controls of their abilities to shape immune responses. This chapter provides the recent progress in the field of IL-17 studies for the understanding of the regulatory mechanisms in the expression and signaling of the IL-17 family cytokines. IL-17A (IL-17) is the most well-studied member in this family, while information on the other members is relatively sketchy. Thus, we mainly focus on the study of IL-17A.