Visual Cortical Prosthesis with a Geomagnetic Compass Restores Spatial Navigation in Blind Rats
Visual Cortical Prosthesis with a Geomagnetic Compass Restores Spatial Navigation in Blind Rats
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DOI：
10.1016/j.cub.2015.02.063
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发表时间：
2015-04
期刊：
影响因子：
9.2
通讯作者：
H. Norimoto;Y. Ikegaya
中科院分区：
文献类型：
--
作者：
H. Norimoto;Y. Ikegaya
异中心感是空间导航的主要组成部分之一[1,2]。在盲人患者中，空间探索的困难至少部分归因于绝对方向感知的缺陷[3,4]。为了支持这一观点，我们宣布失明的成年大鼠在外部提供其头部方向的实时反馈时可以正常执行空间任务。将头戴式微刺激器与数字地磁罗盘一起植入眼睑缝合的成年大鼠的初级视觉皮层。这些“盲”老鼠被训练在t形迷宫或更复杂的迷宫中寻找食物颗粒。在几十次试验中，他们学会了管理地磁信息源来解开迷宫。它们的表现水平和导航策略与视力正常的完整大鼠相似。因此，盲鼠可以通过外部提供的立体定向线索识别自我定位。
Allocentric sense is one of the major components that underlie spatial navigation [1, 2]. In blind patients, the difficulty in spatial exploration is attributed, at least partly, to the deficit of absolute direction perception [3, 4]. In support of this notion, we announce that blind adult rats can perform spatial tasks normally when externally provided with real-time feedback of their head directions. Head-mountable microstimulators coupled with a digital geomagnetic compass were bilaterally implanted in the primary visual cortex of adult rats whose eyelids had been sutured. These "blind" rats were trained to seek food pellets in a T-shaped maze or a more complicated maze. Within tens of trials, they learned to manage the geomagnetic information source to solve the mazes. Their performance levels and navigation strategies were similar to those of normal sighted, intact rats. Thus, blind rats can recognize self-location through extrinsically provided stereotactic cues.