RGD island spacing controls phenotype of primary human fibroblasts adhered to ligand-organized hydrogels

RGD island spacing controls phenotype of primary human fibroblasts adhered to ligand-organized hydrogels
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DOI:
10.1007/bf03218816
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发表时间:
2007-08-01
影响因子:
2.4
通讯作者:
Mooney, David J.
Mooney, David J.
中科院分区:
工程技术4区
文献类型:
--
作者:
Bae, Min-Su;Lee, Kuen Yong;Mooney, David J.

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事实证明,在纳米水平上改变藻酸盐凝胶中 RGD 肽之间的距离能够控制原代人成纤维细胞的表型,这对于组织工程应用的聚合物支架的设计和定制可能至关重要。
Varying the distance between the RGD peptides in alginate gels at the nanometer level was demonstrated to be able to control the phenotype of primary human fibro-blasts, which may be critical in the design and tailoring of polymeric scaffolds for applications in tissue engineering.