Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
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DOI：
10.1155/2012/192503
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发表时间：
2012
影响因子：
4.7
通讯作者：
Juel Rasmussen L
中科院分区：
文献类型：
--
作者：
Desler C;Hansen TL;Frederiksen JB;Marcker ML;Singh KK;Juel Rasmussen L
氧化磷酸化是高能量需求组织中不可缺少的ATP来源。如果ATP需求得不到满足，研究表明这将导致受影响组织的衰老和细胞死亡。术语储备呼吸能力或备用呼吸能力用于描述在能量需求突然增加的情况下可以通过氧化磷酸化产生的额外ATP的量。储备呼吸能力的消耗与影响高能量需求组织的一系列病理学有关。在生物体的老化过程中，由于线粒体功能障碍，氧化磷酸化的效率下降。基于需要能量的组织如大脑，心脏和骨骼肌的例子，我们提出与年龄相关的氧化磷酸化下降降低了受影响组织的储备呼吸能力，使细胞对ATP需求激增敏感，并增加了由此产生的病理学风险。
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.