β2‐glycoprotein 1 (β2GP1) enhances cardiolipin binding activity but is not the antigen for antiphospholipid antibodies
β2‐glycoprotein 1 (β2GP1) enhances cardiolipin binding activity but is not the antigen for antiphospholipid antibodies
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β2-糖蛋白 1 (β2GP1) 增强心磷脂结合活性，但不是抗磷脂抗体的抗原
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
G. DeLorenzo
中科院分区：
文献类型：
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作者：
S. Pierangeli;E. Harris;S. Davis;G. DeLorenzo
Summary. Some investigators have reported that a serum protein, β2‐glycoprotein 1 (β2GP1), either alone or in combination with negatively charged phospholipid, may be the antigen for anticardiolipin (aCL) antibodies. To examine these reports further, ELISA tests, inhibition experiments, Ouchterlony and Western blot techniques were used to examine anticardiolipin binding to β2GP1. Sera from patients with the antiphospholipid syndrome (APS) and syphilis were studied, as well as whole IgG immunoglobulin and affinity purified (a.p.) IgG aCL antibodies. Results showed no binding of aCL antibodies to β2GP1 in the absence of cardiolipin.
