Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy.
Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy.
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DOI：
10.1016/j.hroo.2020.12.021
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Huizar JF
中科院分区：
文献类型：
--
作者：
Torrado J;Kowlgi GN;Ramirez RJ;Balderas-Villalobos J;Jovin D;Parker C;Om E;Airapetov S;Kaszala K;Tan AY;Ellenbogen KA;Huizar JF
心动过速和心率不规则被认为是室性早搏诱发心肌病（室性早搏心肌病）的诱因。双侧心房和室性早搏（PACs和室性早搏）增加心率并导致心律不规则，但对心室同步的影响不同。将慢性双性心肌病与室性早搏进行比较将有助于了解室性早搏-心肌病的发病机制。比较慢性PACs和室性早搏对心室血流动力学、结构和功能的影响。将心脏起搏器植入27只犬体内，以繁殖心房（PACs, n = 7）或心室双裂（PVCs, n = 11），持续12周，并与假手术动物（n = 9）进行比较。另外4只动物长期暴露于双性早搏（48周）。在基线和12周时使用压力传导导管评估血流动力学变化。在12周和48周的治疗过程中，通过经胸超声心动图监测各组的心脏重构。PVC组在12周时左室射血分数和收缩力（max dP/dt）显著降低，左室体积缩小（min dP/dt），左室尺寸和质量增加，16周后无进一步恶化。尽管左室质量增加，但相对壁厚减少，与偏心肥厚一致。在12周时，假手术组和PAC组均未发现明显的心脏重构。与双性心肌病相比，室性早搏导致心肌病，其特征是左室射血分数降低，左室扩张和偏心肥大，在12至16周之间趋于平稳。慢性PACs缺乏重构提示心动过速和心率不规则在室性早搏-心肌病的发展中没有显著作用。
Tachycardia and heart rate irregularity are proposed triggers of premature ventricular contraction–induced cardiomyopathy (PVC-cardiomyopathy). Bigeminal premature atrial and ventricular contractions (PACs and PVCs) increase heart rate and result in rhythm irregularities but differ in their effects on ventricular synchrony. Comparing chronic bigeminal PACs with PVCs would provide insights into mechanisms of PVC-cardiomyopathy. To compare the impact of chronic PACs and PVCs on ventricular hemodynamics, structure, and function. Pacemakers were implanted in 27 canines to reproduce atrial (PACs, n = 7) or ventricular bigeminy (PVCs, n = 11) for 12 weeks, and compared to sham-operated animals (n = 9). Four additional animals were exposed to long-term bigeminal PVCs (48 weeks). Hemodynamic changes were assessed using a pressure-transducing catheter at baseline and 12 weeks. Cardiac remodeling was monitored by transthoracic echocardiography throughout the 12- and 48-week protocols in the respective groups. PVC group demonstrated a significant decrease in left ventricular (LV) ejection fraction and contractility (max dP/dt), impaired LV lusitropy (min dP/dt), and increase in LV dimensions and LV mass at 12 weeks without further deterioration beyond 16 weeks. Despite increased LV mass, relative wall thickness decreased, consistent with eccentric hypertrophy. No significant cardiac remodeling was noted in either sham or PAC groups at 12 weeks. In contrast to bigeminal PACs, PVCs result in a cardiomyopathy characterized by reduced LV ejection fraction, LV dilation, and eccentric hypertrophy that plateaus between 12 and 16 weeks. The lack of remodeling in chronic PACs suggests that tachycardia and heart rate irregularity do not play a significant role on the development of PVC-cardiomyopathy.
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影响因子：
5.5
作者：
Jiang M;Zhang M;Howren M;Wang Y;Tan A;Balijepalli RC;Huizar JF;Tseng GN
通讯作者：
Tseng GN
DOI：
10.1161/circep.115.003047
发表时间：
2015-10
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
Potfay J;Kaszala K;Tan AY;Sima AP;Gorcsan J 3rd;Ellenbogen KA;Huizar JF
通讯作者：
Huizar JF
影响因子：
15.9
作者：
Grossman, William;Paulus, Walter J.
通讯作者：
Paulus, Walter J.
影响因子：
2.7
作者：
Gunda, Sampath;Akyeampong, Daniel;Huizar, Jose F.
通讯作者：
Huizar, Jose F.
DOI：
10.1161/circep.111.962381
发表时间：
2011-08
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
Huizar JF;Kaszala K;Potfay J;Minisi AJ;Lesnefsky EJ;Abbate A;Mezzaroma E;Chen Q;Kukreja RC;Hoke NN;Thacker LR 2nd;Ellenbogen KA;Wood MA
通讯作者：
Wood MA