The effects of cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC) on milk lipid synthesis in mammary glands of dairy cows
The effects of cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC) on milk lipid synthesis in mammary glands of dairy cows
复制标题
细胞死亡诱导DNA碎片因子α样效应子C (CIDEC)对奶牛乳腺乳脂合成的影响
DOI：
10.3168/jds.2016-11549
复制
发表时间：
2017-05-01
影响因子：
3.5
通讯作者：
Hou, Xiaoming
中科院分区：
文献类型：
--
作者：
Yang, Yang;Lin, Ye;Hou, Xiaoming
哺乳期间乳腺的充足脂质合成对于哺乳动物后代的存活至关重要。细胞死亡诱导DNA片段化因子-α样效应子C（CIDEC）是一种脂滴相关蛋白，在小鼠和人脂肪细胞中具有促进脂质蓄积和抑制脂解的功能。然而，CIDEC在调节奶牛乳腺中的乳脂合成中的功能在很大程度上仍然未知。在这项研究中，6头泌乳早期的经产荷斯坦奶牛（胎次= 3）被分配到高脂奶（产奶量33.9 +/- 2.1 kg/d，乳脂> 3.5%，n = 3）和低脂奶（产奶量33.7 +/- 0.5 kg/d，乳脂> 3.5%，
Adequate lipid synthesis by the mammary gland during lactation is essential for the survival of mammalian offspring. Cell death-inducing DNA fragmentation factor-alpha-like effector C (CIDEC) is a lipid droplet-associated protein and functions to promote lipid accumulation and inhibit lipolysis in mice and human adipocytes. However, the function of CIDEC in regulation of milk lipid synthesis in dairy cow mammary gland remains largely unknown. In this study, 6 multiparous Holstein cows (parity = 3) in early lactation were allocated to high-fat milk (milk yield 33.9 +/- 2.1 kg/d, milk fat >3.5%, n = 3) and low-fat milk (milk yield 33.7 +/- 0.5 kg/d, milk fat