Spectroscopic diagnosis of bladder cancer with elastic light scattering
Spectroscopic diagnosis of bladder cancer with elastic light scattering
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DOI：
10.1002/lsm.1900170403
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发表时间：
1995-01-01
影响因子：
2.4
通讯作者：
Shimada, T
中科院分区：
文献类型：
--
作者：
Mourant, JR;Bigio, IJ;Shimada, T
背景和目标：最近，已经取得了显着的进展，朝着发展的光学，非侵入性的医疗诊断，本研究的目标是评估弹性散射测量作为诊断膀胱cancer.Study设计/材料和方法的工具：在体内测量10例疑似膀胱癌的光学活检系统（OBS）在洛斯阿拉莫斯国家实验室开发。弹性散射光谱的波长范围为250-800 nm，使用光纤探头通过一个腔的泌尿膀胱镜。测量是在脓疱正常区域和不确定的异常区域，以及那些怀疑是癌症的区域。在用OBS进行测量后，在测量部位采集活检样本。比较的组织病理学和光学光谱，然后made.Results和结论：一个诊断算法区分恶性与非恶性组织的基础上的值的斜率在波长范围330-370 nm的灵敏度为100%，特异性为97%，在这项研究中的患者数量有限。(C)1995年Wiley-Liss，Inc.*。
Background and Objectives: Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics, The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer.Study Design/Materials and Methods: In vivo measurements on 10 patients with suspected bladder cancer were made with the optical biopsy system (OBS) developed at Los Alamos National Laboratory. Elastic-scatter spectra over the wavelength range 250-800 nm were obtained using a fiber-optic probe through one of the lumens of a urological cystoscope. Measurements were made on putatively normal areas and areas of uncertain abnormality, as well as those suspected to be cancerous. After measurements were made with the OBS, biopsy samples were taken at the measurement sites. Comparisons of the histopathology and the optical spectra were then made.Results and Conclusions: A diagnostic algorithm for distinguishing malignant from nonmalignant tissue based on the values of the slopes over the wavelength range 330-370 nm has a sensitivity of 100% and specificity of 97% for the limited number of patients in this study. (C) 1995 Wiley-Liss, Inc.*.