Periodic limb movements and restless legs syndrome in children with a history of prematurity.
Periodic limb movements and restless legs syndrome in children with a history of prematurity.
复制标题
有早产史的儿童出现周期性肢体运动和不宁腿综合征。
DOI：
10.1016/j.sleep.2016.02.009
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发表时间：
2017
期刊：
影响因子：
4.8
通讯作者：
CaffeineforApneaofPrematurity–SleepStudyGroup
中科院分区：
文献类型：
--
作者：
Cielo,ChristopherM;DelRosso,LourdesM;Tapia,IgnacioE;Biggs,SarahN;Nixon,GillianM;Meltzer,LisaJ;Traylor,Joel;Kim,JiYoung;Marcus,CaroleL;CaffeineforApneaofPrematurity–SleepStudyGroup
关于不宁腿综合征（RLS）和周期性肢体运动障碍（PLMD）风险增加的儿科人群知之甚少。来自咖啡因治疗早产睡眠呼吸暂停（CAPS）研究的多导睡眠图数据显示，在一组早产儿中，周期性肢体运动指数（PLMI）升高的发生率很高，但这一发现的临床重要性，如与睡眠动脚症的关联，尚不清楚。我们假设前早产儿有较高的RLS和PLMD患病率。方法加入CAPS的性别早产儿，年龄5-12岁，完成家庭多导睡眠描记（PSG）和标准化问卷。符合国际睡眠障碍分类第三版标准的参与者根据问卷调查和多导睡眠图确定了RLS或PLMD的诊断。评估临床可用的血清铁蛋白水平。结果167名参与者接受了多导睡眠描记术，并完成了所有问卷调查。RLS的总患病率为14/167（8.4%）。另有13例（7.8%）被发现患有PLMD。在26名PLMI患者中，7名（26.9%）患有RLS， 13名（50%）患有PLMD。所有8名接受检测的受试者血清铁蛋白水平均<50微克/升（范围- 38.4）。结论有早产史的儿童有较高的RLS患病率，尤其是周期性肢体运动增加的儿童。缺铁可能导致该人群出现RLS和PLMD症状。临床医生评估有睡眠障碍的前早产儿时，应评估RLS和PLMD。需要进一步的研究，包括血清铁蛋白评估来证实这些发现。
IntroductionLittle is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity–Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as association with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD.MethodsEx-preterm children enrolled in CAPS, now aged 5–12 years, completed home polysomnography (PSG) and standardized questionnaires. A diagnosis of RLS or PLMD was established by participants meeting the International Classification of Sleep Disorders, 3rd edition, criteria based on questionnaires and polysomnograms. The clinically available serum ferritin levels were assessed.ResultsIn total, 167 participants underwent polysomnography and completed all questionnaires. The overall prevalence of RLS was 14/167 (8.4%). An additional 13 subjects (7.8%) were found to have PLMD. Of the 26 participants who had PLMI > 5/h, seven (26.9%) had RLS and 13 (50%) had PLMD. The serum ferritin levels were <50 mcg/L (range −38.4) for all eight participants referred for testing.ConclusionsChildren with a history of prematurity have a high prevalence of RLS, particularly those with elevated periodic limb movements. Iron deficiency likely contributes to RLS and PLMD symptoms in this population. Clinicians evaluating ex-preterm children with sleep disturbances should evaluate for RLS and PLMD. Further studies including serum ferritin evaluation are required to confirm these findings.