Left ventricular torsion based on 2D speckle tracking echocardiography (STE) is preload insensitive
Left ventricular torsion based on 2D speckle tracking echocardiography (STE) is preload insensitive
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基于 2D 斑点追踪超声心动图 (STE) 的左心室扭转对前负荷不敏感
DOI：
10.1096/fasebj.26.1_supplement.864.15
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
L. Sinoway
中科院分区：
文献类型：
--
作者：
Zhaohui Gao;R. Drew;A. Momen;I. Ndukwu;M. Muller;J. Mast;Cheryl A. Blaha;U. Leuenberger;L. Sinoway
左室扭转在心肌功能中起着重要作用。2D特殊跟踪超声心动图（STE）已成为LV扭转分析的一种有前途的工具。尚不清楚左心室扭转是否受到前负荷改变的影响。我们试图确定通过下体负压（LBNP）急性前负荷减少是否影响2D STE衍生的LV扭转参数。通过2D STE测量了12名健康受试者（26±1岁，6名女性）在LBNP达到-10、-20、-30、-40和-50 mmHg水平之前和期间的LV顶端和基底旋转以及峰值舒张早期扭转率。LV总扭转计算为收缩期心尖逆时针旋转和基底顺时针旋转之间的净差。还测量了舒张早期峰值扭转率。与基线相比，LBNP导致左室舒张末期容积（P<0.05）和每搏输出量（P<0.01）显著降低，而心率增加（P<0.01）。左室扭转的多项指标，包括左室总扭转、心尖旋转和基底旋转以及舒张早期峰值扭转率，均不受LBNP影响（均P>0.05）。这些数据支持通过2D STE评估的LV扭转参数是心肌功能的前负荷独立指标的概念。因此，通过2D STE量化LV扭转可以提供相对与负荷无关的心肌性能测量。
Left ventricular (LV) torsion plays an important role in myocardial performance. 2D special tracking echocardiography (STE) has emerged as a promising tool for LV torsion analysis. It is unknown if LV torsion is affected by alterations in preload. We sought to determine whether acute preload reduction by Lower Body Negative Pressure (LBNP) affects 2D STE derived LV torsion parameters. LV apical and basal rotation and peak early diastolic torsional rate were measured by 2D STE in 12 healthy subjects (26±1 yrs, 6 females) before and during LBNP to −10, −20, −30, −40 and −50 mmHg levels. LV total torsion was calculated as the net difference between systolic apical counterclockwise rotation and basal clockwise rotation. Peak early diastolic torsional rate was also measured. Compared to baseline, LBNP caused significant decreases in LV end‐diastolic volume (P<0.05) and stroke volume (P<0.01) while heart rate increased (P<0.01). Interestingly, multiple indices of LV torsion including LV total torsion, apical and basal rotation and peak early diastolic torsional rate, were unaffected by LBNP (all P>0.05). These data support the concept that LV torsion parameters assessed by 2D STE are preload‐independent indices of myocardial function. Quantification of LV torsion by 2D STE may, therefore, provide a relatively load‐independent measure of myocardial performance.