Sponging off nature for new drug leads
Sponging off nature for new drug leads
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DOI：
10.1016/j.bcp.2017.04.012
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发表时间：
2017-09-01
影响因子：
5.8
通讯作者：
Andersen, Raymond J.
中科院分区：
文献类型：
--
作者：
Andersen, Raymond J.
海洋海绵一直是新的海洋天然产品的最丰富来源，具有前所未有的化学支架和强大的生物活性，自1970年代初以来，化学文献中就有报道。在过去的40年里，不列颠哥伦比亚大学安德森实验室的化学家与生物学家合作，发现了许多新的生物活性海绵天然产物。四种用于治疗炎症和癌症的实验性候选药物，受到这种海绵天然产物收藏品成员的启发，已经进展到临床试验阶段。这篇综述叙述了这四种候选药物的发现和开发背后的科学故事; IPL 576，092，HTI-286（Taltobulin），EPI-506（醋酸雷拉尼顿）和AQX-1125。(C)2017爱思唯尔公司All rights reserved.
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities that have been reported in the chemical literature since the early 1970s. During the last 40 years, chemists in the Andersen laboratory at UBC, in collaboration with biologists, have discovered many novel bioactive sponge natural products. Four experimental drug candidates for treatment of inflammation and cancer, that were inspired by members of this sponge natural product collection, have progressed to phase clinical trials. This review recounts the scientific stories behind the discovery and development of these four drug candidates; IPL576,092, HTI-286 (Taltobulin), EPI-506 (Ralaniten acetate), and AQX-1125. (C) 2017 Elsevier Inc. All rights reserved.