p53 Family: Role of Protein Isoforms in Human Cancer.
p53 Family: Role of Protein Isoforms in Human Cancer.
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DOI：
10.1155/2012/687359
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发表时间：
2012
影响因子：
2.3
通讯作者：
Zaika A
中科院分区：
文献类型：
--
作者：
Wei J;Zaika E;Zaika A
TP53、TP63和TP73基因组成p53家族。每个基因通过多种机制产生蛋白质亚型，包括广泛的mRNA剪接。越来越多的证据表明，这些异构体在正常细胞中的许多生物学过程的调节中起着关键作用。它们的异常表达有助于肿瘤的发生，并对肿瘤对治愈性治疗的反应具有深远的影响。本文综述了p53家族的异构体多样性及其在癌症中的作用。
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.