Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
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DOI：
10.1016/s0968-0896(03)00523-6
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发表时间：
2003-11-03
影响因子：
3.5
通讯作者：
Kwon, HJ
中科院分区：
文献类型：
--
作者：
Jung, HJ;Lee, HB;Kwon, HJ
Cochlioquinone Al (CoA1) 是新近从 Bipolaris zeicola 的培养物提取物中分离出来的，作为一种有效的抗血管生成剂。 CoA1 在一定浓度 (1 mug/mL) 下可抑制牛主动脉内皮细胞 (BAEC) 的体外血管生成，例如 bFGF 诱导的管形成和侵袭，且无细胞毒性。值得注意的是，CoA1 对 BAEC 的生长表现出比本研究中研究的正常细胞系和癌细胞系更有效的抑制活性。这些结果表明CoA1是一种新的抗血管生成剂，可以开发为血管生成相关疾病的新治疗剂。 (C) 2003 Elsevier Ltd. 保留所有权利。
Cochlioquinone Al (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 mug/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases. (C) 2003 Elsevier Ltd. All rights reserved.