Gold-Nanobipyramid-Based Nanotheranostics for Dual-Modality Imaging-Guided Phototherapy
Gold-Nanobipyramid-Based Nanotheranostics for Dual-Modality Imaging-Guided Phototherapy
复制标题
基于金纳米双锥的纳米治疗学用于双模态成像引导光疗
DOI：
10.1021/acsami.0c00112
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发表时间：
2020-03-18
影响因子：
9.5
通讯作者：
Li, Zhiming
中科院分区：
文献类型：
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作者：
Li, Chunxiao;Mei, Enci;Li, Zhiming
多模态影像引导治疗可以提高肿瘤的诊断和治疗效率。在此，我们开发了一种基于吲哚菁绿色（ICG）共轭介孔二氧化硅包覆的金纳米双金字塔（GNB@SiO2）（表示为GNB@SiO2-ICG）的光响应纳米治疗剂，用于同时荧光（FL）/光声（PA）成像引导的光热治疗（PTT）。具有优异光稳定性的GNB@SiO2用于PA成像以及PTT。加载的ICG承诺FL成像和PTT。从癌细胞到小鼠评估GNB@SiO2-ICG的癌症治疗诊断能力的可行性。在FL/PA成像引导下，GNB@SiO2-ICG治疗效果明显增强，可完全消除肿瘤组织，无肿瘤复发。这种定义明确的纳米治疗诊断纳米平台智能地集成了双模态成像和光疗，为癌症纳米治疗诊断提供了一个有效的纳米平台。
Multimodality imaging-guided therapy can improve the diagnostics and therapeutics efficiency of cancer. Herein, we developed a light-responsive nanotheranostic agent based on the indocyanine green (ICG) conjugated mesoporous silica coated gold nanobipyramid (GNB@SiO2) (denoted as GNB@SiO2-ICG) for simultaneous fluorescence (FL)/photoacoustic (PA) imaging-guided photothermal therapy (PTT). The GNB@SiO2 with excellent photostability was used for PA imaging as well as PTT. The loaded ICG promised FL imaging and PTT. The feasibility of the cancer theranostic capability of GNB@SiO2-ICG was evaluated from cancer cells to mice. Under the guidance of FL/PA imaging, GNB@SiO2-ICG exhibited remarkably enhanced therapeutic efficacy, which could eliminate the tumor tissues completely without tumor recurrence. This well-defined nanotheranostic nanoplatform that intelligently integrates dual-modality imaging and phototherapy provides an efficient nanoplatform for cancer nanotheranostics.