HUMAN CD5+ B-LYMPHOCYTES (B-1 CELLS) DECREASE IN PERIPHERAL-BLOOD DURING PREGNANCY
HUMAN CD5+ B-LYMPHOCYTES (B-1 CELLS) DECREASE IN PERIPHERAL-BLOOD DURING PREGNANCY
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DOI：
10.1016/0165-0378(94)00907-o
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发表时间：
1995-01-01
影响因子：
3.4
通讯作者：
TENG, NNH
中科院分区：
文献类型：
--
作者：
BHAT, NM;MITHAL, A;TENG, NNH
妊娠是一种独特的免疫状态，其中抗原性不同的组织之间存在自然的稳态。几项早期的研究已经讨论了淋巴细胞（包括妊娠期间的B细胞）数量和/或功能的波动，但尚未讨论B淋巴细胞亚群（常规（CD 5（-））和B-1（CD 5（+）内的变化。在这里，我们证明了B-1细胞的频率在怀孕期间急剧下降，而传统的B细胞的频率保持相对恒定。缺失的B-1细胞在分娩后8-10周恢复到妊娠前水平。由B-1细胞分泌的多反应性自身抗体与自身免疫和免疫调节有关。B-1细胞在怀孕期间的可能作用将在这种情况下进行讨论。
Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5(-)) and B-1 (CD5(+)), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8-10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.