Model‐based control of batch chromatography
Model‐based control of batch chromatography
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基于模型的批量色谱控制
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
H. Schmidt
中科院分区：
文献类型：
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作者：
G. Dünnebier;S. Engell;Achim Epping;Felix Hanisch;A. Jupke;K. Klatt;H. Schmidt
在化学工业中，生命科学产品被认为是近期最有前途的市场。由于药品、食品和精细化学品受到越来越复杂的标准和更严格的法律限制，因此需要分离热不稳定产品的有效方法。例如，色谱分离通常是整个生产过程的主要成本。为了充分发挥色谱分离的潜力，必须保持所需的产品质量，同时通过可靠和有效的过程监测和控制，以经济最佳的方式运行过程。对间歇色谱的控制进行了模型参数估计和操作参数在线优化。该概念已在实验室规模的工业过程控制系统上进行了测试。给出了糖分离的实验结果。
In the chemical industry, life science products are considered the most promising markets for the near future. Since pharmaceutical products, food, and fine chemicals are subject to increasingly more complex standards and stricter legal restrictions, efficient methods for the separation of thermally unstable products are needed. Chromatographic separations, for example, usually create the main costs of the overall production process. To realize the full potential of the chromatographic separation, the desired product quality has to be maintained, while operating the process at the economic optimum by reliable and efficient process monitoring and control. For control of batch chromatography, model parameters were estimated and operating parameters were optimized online. The concept has been tested on a laboratory-scale column with an industrial process control system. Experimental results for a sugar separation are given.