A Toxicological Framework for the Prioritization of Children's Safe Product Act Data.
A Toxicological Framework for the Prioritization of Children's Safe Product Act Data.
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DOI：
10.3390/ijerph13040431
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发表时间：
2016-04-19
影响因子：
--
通讯作者：
Faustman EM
中科院分区：
文献类型：
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作者：
Smith MN;Grice J;Cullen A;Faustman EM
为了回应对儿童产品中危险化学物质的担忧，华盛顿州通过了儿童安全产品法案(CSPA)。CSPA要求制造商报告儿童产品中66种化学物质的浓度。我们描述了CSPA中报告最频繁的十个化学基团的毒理学优先排序框架。该框架对生活方式、接触时间、一次、二次和三次接触途径、毒物动力学和化学性质进行评分，以计算暴露分数。根据精选的国家和国际数据库，评估了四个毒理学终点：生殖和发育毒性、内分泌干扰、神经毒性和致癌性。根据毒性和暴露得分的乘积计算总优先指数。最优先的三种化学品是甲醛、邻苯二甲酸二丁酯和苯乙烯。将该框架的要素与现有的优先排序工具进行了比较，如美国环境保护局(EPA)的ExpoCast和毒理学优先排序指数(ToxPI)。CSPA框架使我们能够以特定于生活年龄的方式检查毒性和接触途径，提供了一种相对较高的吞吐量方法来优先处理儿童产品中发现的危险化学品。
In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products.