Multicentric endocrine mucin‐producing sweat gland carcinoma and mucinous carcinoma of the skin: A case report
Multicentric endocrine mucin‐producing sweat gland carcinoma and mucinous carcinoma of the skin: A case report
复制标题
多中心内分泌粘蛋白汗腺癌和皮肤粘液癌：一例报告
作者：
A. Nishimoto;H. Kuwahara;R. Ohashi;Shin
内分泌粘液性汗腺癌(EMPSGC)是一种罕见的低度汗腺癌。EMPSGC被认为是皮肤粘液癌(MCS)的先兆。自1997年首次描述EMPSGC以来，仅有少数病例被报道，其病因和发病机制尚不清楚。在本报告中，我们描述了一位71岁的日本妇女，她的面部有两个孤立的EMPSGC和一个MCS病变。她同时被诊断为乳腺浸润性导管癌。24 年前，她有不明组织病理学诊断的子宫癌病史。由肌上皮细胞证实的原位病变的存在表明皮肤病变是原发肿瘤。据我们所知，这是首例多原发EMPSGC/MCS肿瘤。此外，这可能是第一例多原发癌，包括附件皮肤肿瘤、乳腺癌和子宫癌，这些肿瘤可能具有表达女性激素受体的共同特征。此病例提示EMPSGC/MCS可能由激素受体异常触发，可能是由于遗传缺陷。为了进一步评估我们的初步意见，可能有必要编写更多的报告来审查这一问题。
Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare low‐grade sweat gland carcinoma. EMPSGC is thought to be a precursor to mucinous carcinoma of the skin (MCS). Since the first description of EMPSGC in 1997, only a few cases have been reported, and its etiology and mechanisms remain unknown. In this report, we describe a 71‐year‐old Japanese woman with two isolated EMPSGC and one MCS lesion on her face. She was simultaneously diagnosed with invasive ductal carcinoma of the breast. She had a history of uterine cancer of unknown histopathological diagnosis 24 years previously. The presence of in situ lesions confirmed by myoepithelial cells suggested that the cutaneous lesions were primary tumors. To the best of our knowledge, this is the first case of multiple primary EMPSGC/MCS tumors. Additionally, this might be the first case with multiple primary carcinomas including adnexal cutaneous tumors, breast cancer, and uterine cancer, which may share the common feature of expressing female hormonal receptors. This case indicates that EMPSGC/MCS may be triggered by a hormonal receptor abnormality, perhaps because of genetic defects. A larger number of reports examining this issue may be necessary to further assess our initial observations.
影响因子：
2
作者：
Burris,ChristopherKH;Raven,MeishaL;Rodriguez,MariaE;Potter,HeatherD;Lucarelli,MarkJ;Albert,DanielM
通讯作者：
Albert,DanielM