Does gender affect human pulmonary gas exchange during exercise?
Does gender affect human pulmonary gas exchange during exercise?
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DOI：
10.1113/jphysiol.2003.056887
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发表时间：
2004-06-01
影响因子：
5.5
通讯作者：
Hopkins, SR
中科院分区：
文献类型：
--
作者：
Olfert, IM;Balouch, J;Hopkins, SR
女性在运动过程中可能比男性经历更大的肺气体交换障碍。为了验证这一点，我们使用多种惰性气体消除技术，研究了年龄、身高和V-O2 max（类似于48 ml kg（-1）min（-1））相匹配的8名女性和7名男性在常氧和低氧（吸入P-O2 = 95 Torr）循环运动中的情况。除女性的一氧化碳弥散量（DLCO）较低外（P < 0.05），两性之间的静息肺功能相似。动脉P-O2、P-CO2和肺泡-动脉氧分压差（A-aD（O2））在男女之间无显著差异。尽管女性的O-2（DLO 2）扩散能力较低，但男女之间的DLO 2/betaQ比值（估计肺毛细血管末端扩散平衡）相似，低氧运动期间的扩散限制估计值在两性之间没有差异。在常氧和低氧运动期间，通气-灌注不平等（由灌注分布的二阶矩描述，logSD（Q））增加。令人惊讶的是，在一定条件下，女性的logSD（Q）值略低（P < 0.05），但这并没有显著影响气体交换。这些数据表明，这些活跃的女性，尽管较低的DLCO和DLO 2，不经历更大的运动引起的异常气体交换比男性匹配的年龄，身高，有氧能力和肺大小。可能健身水平和肺的大小更重要的是确定是否发生在运动过程中肺气体交换损害比性别本身。
Women may experience greater pulmonary gas exchange impairment during exercise than men. To test this we used the multiple inert gas elimination technique to study eight women and seven men matched for age, height and V-O2max (similar to48 ml kg(-1) min(-1)) during normoxic and hypoxic (inspired P-O2 = 95 Torr) cycle exercise. Resting lung function was similar between the sexes, except for a lower carbon monoxide diffusing capacity (DLCO) in women (P < 0.05). Arterial P-O2, P-CO2 and alveolar-arterial O-2 difference (A-aD(O2)) were not significantly different in men and women. Despite a lower diffusing capacity for O-2 (DLO2) in women, the ratio DLO2/betaQ (which estimates pulmonary end-capillary diffusion equilibrium) was similar between men and women and estimates of diffusion limitation during hypoxic exercise were not different between the sexes. Ventilation-perfusion inequality (described by the second moment of the perfusion distribution, logSD(Q)) increased during both normoxic and hypoxic exercise. Surprisingly, logSD(Q) values were slightly lower for women under an conditions (P < 0.05), but this did not significantly affect gas exchange. These data indicate that these active women, despite a lower DLCO and DLO2, do not experience greater exercise-induced abnormalities in gas exchange than men matched for age, height, aerobic capacity and lung size. Possibly fitness level and lung size are more important in determining whether or not pulmonary gas exchange impairment occurs during exercise than sex per se.