Preliminary classification of nonmalignant B cell proliferation in Sjogren's syndrome: Perspectives on pathobiology and treatment based on an integrated clinico-pathologic and molecular study approach
Preliminary classification of nonmalignant B cell proliferation in Sjogren's syndrome: Perspectives on pathobiology and treatment based on an integrated clinico-pathologic and molecular study approach
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DOI：
10.1006/bcmd.2001.0446
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发表时间：
2001-07-01
影响因子：
2.3
通讯作者：
Ferraccioli, G
中科院分区：
文献类型：
--
作者：
De Vita, S;De Marchi, G;Ferraccioli, G
根据关于干燥综合征相关淋巴瘤发生的国际会议的结果和我们的临床病理学和分子研究结果以及对特征良好的患者的长期随访结果，提出了干燥综合征非恶性淋巴细胞增生的分类。干燥综合征的病理学与丙型肝炎病毒相关的B细胞淋巴细胞增生有相似之处。类风湿因子阳性克隆的优先扩增和特异性免疫球蛋白基因表达和重组的抗原刺激代表了淋巴细胞增殖中的关键生物学事件。这种分类是基于分子和组织学研究的结合，并可能导致更有选择性的治疗方法。(C)北京：科学出版社.
A classification of nonmalignant lymphoproliferation in Sjogren's syndrome is presented, based on the results of international meetings regarding Sjogren's syndrome-associated lymphomagenesis and on our results of a clinico-pathologic and molecular study and long-term follow-up in well-characterized patients. Sjogren's syndrome pathobiology has similarities to hepatitis C virus-related B-cell lymphoproliferation. Antigen stimulation with the preferential expansion of rheumatoid factor-positive clones and specific immunoglobulin gene expression and recombination represent key biologic events in lymphoproliferation. This classification is based on the coupling of molecular and histological studies and may result in more selective treatment approaches. (C) 2001 Academic Press.