Minimotif miner: a computational tool to investigate protein function, disease, and genetic diversity.

Minimotif miner: a computational tool to investigate protein function, disease, and genetic diversity.
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DOI:
10.1002/0471140864.ps0212s48
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发表时间:
2007-05-01
影响因子:
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通讯作者:
Schiller, Martin R
Schiller, Martin R
中科院分区:
其他
文献类型:
--
作者:
Schiller, Martin R

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Minimotif Miner网站在一个数据库中包含了数百个短功能基序的信息,并允许用户搜索这些基序存在的蛋白质查询。基于进化保守性、蛋白质表面预测和基序频率的评分可以与其他基序程序和查询的已知生物学结合使用,以减少假阳性预测并选择短基序用于实验追求。
The Minimotif Miner Web site contains information on several hundred short functional motifs in a single database, and allows the user to search protein queries for the presence of these motifs. Scoring based on evolutionary conservation, protein surface prediction, and motif frequency can be used in conjunction with other motif programs and the known biology of the query to reduce false-positive predictions and select short motifs for experimental pursuit.