Gabapentin, ineffective in normal rats, markedly reduces C‐fibre evoked responses after inflammation
Gabapentin, ineffective in normal rats, markedly reduces C‐fibre evoked responses after inflammation
复制标题
加巴喷丁对正常大鼠无效，但可显着降低炎症后 C 纤维诱发反应
DOI：
10.1097/00001756-199702100-00002
复制
发表时间：
1997
期刊：
影响因子：
1.7
通讯作者：
A. Dickenson
中科院分区：
文献类型：
--
作者：
Louise C. Stanfa;L. Singh;Richard G. Williams;A. Dickenson
加巴喷丁（Neurontin）是一种新型抗惊厥药，其作用机制尚不清楚。这项电生理学研究调查了在正常动物中以及注射角叉菜胶引起的炎症后全身施用加巴喷丁的潜在抗伤害作用。加巴喷丁促进了正常动物中记录的背角神经元的有害诱发反应。与此相反，在注射角叉菜胶3小时后记录的动物神经元中，加巴喷丁强烈且剂量依赖性地抑制C纤维诱发反应和放电后反应，但不抑制Aβ纤维诱发反应。加巴喷丁的这种独特且选择性的特征可能为临床炎症疼痛状态提供一种新的治疗方法。
GABAPENTIN (Neurontin) is a novel anticonvulsant with an as yet unknown mechanism of action. This electrophysiological study investigated the potential antinociceptive actions of systemically administered gabapentin in normal animals and after inflammation induced by the injection of carrageenan. Gabapentin facilitated the noxious evoked responses of dorsal horn neurones recorded in normal animals. In complete contrast, gabapentin strongly and dose-dependently inhibited the C-fibre evoked response and post-discharge, but not the Aβ-fibre evoked response, of neurones recorded in animals 3 h after the injection of carrageenan. This unique and selective profile of gabapentin may provide a novel treatment for clinical inflammatory pain states.