The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis
The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis
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DOI：
10.1016/j.febslet.2007.01.072
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发表时间：
2007-03-06
期刊：
影响因子：
3.5
通讯作者：
D'Alessio, Giuseppe
中科院分区：
文献类型：
--
作者：
Monti, Daria Maria;Gesualdi, Nicola Montesano;D'Alessio, Giuseppe
通过检测氧化剂和抗氧化剂对正常、原代内皮HUVE细胞和恶性HeLa细胞在构建CRI缺失细胞前后的影响，探讨了胞质核糖核酸酶抑制物(CRI)对细胞氧化还原动态平衡的保护作用。我们发现CRI在保护细胞免受氧化还原应激中起着重要的、可能是关键的生理作用，在CRI缺失的细胞中，GSH水平的降低以及氧化剂诱导的DNA损伤的增加证明了这一点。(C)2007年欧洲生化学会联合会。爱思唯尔出版，版权所有。
The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.